SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression

Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state. The restricted and reciprocal expression of the collagen X gene, Col10a1, in hypertrophic chondrocytes and Sox9 in immature cho...

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Veröffentlicht in:	PLoS genetics 2011-11, Vol.7 (11), p.e1002356-e1002356
Hauptverfasser:	Leung, Victor Y L, Gao, Bo, Leung, Keith K H, Melhado, Ian G, Wynn, Sarah L, Au, Tiffany Y K, Dung, Nelson W F, Lau, James Y B, Mak, Angel C Y, Chan, Danny, Cheah, Kathryn S E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biology Bone Development - genetics Cartilage Cartilage - growth & development Cartilage cells Cell cycle Cell Differentiation - genetics Chondrocytes - cytology Chondrocytes - metabolism Chondrogenesis - genetics Collagen Collagen Type II - genetics Collagen Type X - genetics Competition Councils Enhancer Elements, Genetic - genetics Experiments Fetuses Gene expression Gene Expression Regulation, Developmental Genetic aspects Growth Plate - growth & development Hedgehog Proteins - genetics Kruppel-Like Transcription Factors - genetics Mice Mice, Transgenic Molecular Sequence Data Mutation Nucleotide Motifs - genetics Physiological aspects Promoter Regions, Genetic Signal Transduction SOX9 Transcription Factor - metabolism Transcription factors Transcriptional Activation Zinc Finger Protein GLI1
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