ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans

Aging is a complex phenotype responsive to a plethora of environmental inputs; yet only a limited number of transcriptional regulators are known to influence life span. How the downstream expression programs mediated by these factors (or others) are coordinated into common or distinct set of aging e...

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Veröffentlicht in:	PLoS genetics 2010-09, Vol.6 (9), p.e1001125
Hauptverfasser:	Thyagarajan, Bargavi, Blaszczak, Adam G, Chandler, Katherine J, Watts, Jennifer L, Johnson, W Evan, Graves, Barbara J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Base Sequence Biochemistry/Transcription and Translation Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cancer Cell adhesion & migration Developmental Biology/Aging Developmental Biology/Cell Differentiation DNA, Helminth - metabolism Forkhead Transcription Factors Gene Deletion Gene expression Gene Expression Regulation, Developmental Genes, Helminth - genetics Genetic aspects Genetic regulation Genetics Genetics and Genomics Genetics and Genomics/Animal Genetics Genetics and Genomics/Bioinformatics Genetics and Genomics/Gene Discovery Genetics and Genomics/Gene Expression Genetics and Genomics/Gene Function Genetics and Genomics/Genomics Insulin Insulin - metabolism Insulin-Like Growth Factor I - metabolism Intestines - metabolism Larva - growth & development Larva - metabolism Life spans (Biology) Lipids Longevity - genetics Measurement Models, Genetic Molecular Biology/Bioinformatics Molecular Biology/Transcription Initiation and Activation Mutation - genetics Organ Specificity - genetics Oviposition - genetics Protein Binding Proteins Signal Transduction - genetics Studies Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Tumors
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