Ancestral genes can control the ability of horizontally acquired loci to confer new traits

Horizontally acquired genes typically function as autonomous units conferring new abilities when introduced into different species. However, we reasoned that proteins preexisting in an organism might constrain the functionality of a horizontally acquired gene product if it operates on an ancestral p...

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Veröffentlicht in:	PLoS genetics 2011-07, Vol.7 (7), p.e1002184-e1002184
Hauptverfasser:	Chen, H Deborah, Jewett, Mollie W, Groisman, Eduardo A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biology DNA, Bacterial - chemistry DNA, Bacterial - genetics Drug Resistance, Bacterial - genetics Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Expression Regulation, Bacterial Gene Transfer, Horizontal Genes Genetic aspects Kinetics Magnesium - pharmacology Molecular Sequence Data Phosphorylation Physiological aspects Polymyxin B - pharmacology Proteins Reverse Transcriptase Polymerase Chain Reaction Salmonella Salmonella typhimurium - drug effects Salmonella typhimurium - genetics Salmonella typhimurium - metabolism Sequence Analysis, DNA Transcription Factors - genetics Transcription Factors - metabolism Transformation, Bacterial
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