Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate
A central issue of myogenesis is the acquisition of identity by individual muscles. In Drosophila, at the time muscle progenitors are singled out, they already express unique combinations of muscle identity genes. This muscle code results from the integration of positional and temporal signalling in...
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| Veröffentlicht in: | PLoS genetics 2011-07, Vol.7 (7), p.e1002186-e1002186 |
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| creator | Carrasco-Rando, Marta Tutor, Antonio S Prieto-Sánchez, Silvia González-Pérez, Esther Barrios, Natalia Letizia, Annalisa Martín, Paloma Campuzano, Sonsoles Ruiz-Gómez, Mar |
| description | A central issue of myogenesis is the acquisition of identity by individual muscles. In Drosophila, at the time muscle progenitors are singled out, they already express unique combinations of muscle identity genes. This muscle code results from the integration of positional and temporal signalling inputs. Here we identify, by means of loss-of-function and ectopic expression approaches, the Iroquois Complex homeobox genes araucan and caupolican as novel muscle identity genes that confer lateral transverse muscle identity. The acquisition of this fate requires that Araucan/Caupolican repress other muscle identity genes such as slouch and vestigial. In addition, we show that Caupolican-dependent slouch expression depends on the activation state of the Ras/Mitogen Activated Protein Kinase cascade. This provides a comprehensive insight into the way Iroquois genes integrate in muscle progenitors, signalling inputs that modulate gene expression and protein activity. |
| doi_str_mv | 10.1371/journal.pgen.1002186 |
| format | Article |
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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Carrasco-Rando M, Tutor AS, Prieto-Sánchez S, González-Pérez E, Barrios N, et al. (2011) Drosophila Araucan and Caupolican Integrate Intrinsic and Signalling Inputs for the Acquisition by Muscle Progenitors of the Lateral Transverse Fate. 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This provides a comprehensive insight into the way Iroquois genes integrate in muscle progenitors, signalling inputs that modulate gene expression and protein activity.</description><subject>Acquisitions & mergers</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Base Sequence</subject><subject>Biology</subject><subject>Cell Line</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - cytology</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Embryo, Nonmammalian - embryology</subject><subject>Embryo, Nonmammalian - metabolism</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genetic aspects</subject><subject>Genomics</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>In Situ Hybridization</subject><subject>Insects</subject><subject>Kinases</subject><subject>Microscopy, Confocal</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Muscle Development - genetics</subject><subject>Muscles - embryology</subject><subject>Muscles - metabolism</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>ras Proteins - metabolism</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Signal Transduction - genetics</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Zebrafish</subject><issn>1553-7404</issn><issn>1553-7390</issn><issn>1553-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqVk1trHSEQx5fS0qRpv0FpFwotfTin67q76ksgpLdAaKC3V5njjnsMHt2oG5rv0Q9czyUhB_rQ4oM6_uY_OuMUxXNSzQll5N2ln4IDOx8HdHNSVTXh3YPikLQtnbGmah7eWx8UT2K8rCracsEeFweZJaQh3WHx-33w0Y9LY6GEAJMCV4LrSwXT6K1Zb41LOARIuF4F46JRGySaIce3xg35YJxSLLUPZVpiCepqMtEk4125uClXU1QWyzH4fFWTfIil1xvQZtUAtkwBXLzGELHU2fS0eKTBRny2m4-KHx8_fD_9PDu_-HR2enI-U51gaVYDMNY3PaG60a1QrK45EoF9Q2HBWStQ9Jwhat4LYLym0Ci-EHUjVKs0rehR8XKrO1of5S6hURJKaEsY410mzrZE7-FSjsGsINxID0ZuDD4MEkIy-XmSK9IyAFSiUzkCLAgi552uhVYoGGSt4120abHCXmHOJtg90f0TZ5Zy8NeS5lJVpM0Cb3YCwV9NGJNcmajQWnDopyg5JxUXLasz-WpLDpBvZpz2WVCtaXlSdzS_rN5Q879QefS4Mso71Cbb9xze7jlkJuGvNMAUozz79vU_2C__zl783Gdf32OXCDYto7fT-rPFfbDZgir_8BhQ32WaVHLdQbcFl-sOkrsOym4v7lfpzum2Zegf_AQaoA</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Carrasco-Rando, Marta</creator><creator>Tutor, Antonio S</creator><creator>Prieto-Sánchez, Silvia</creator><creator>González-Pérez, Esther</creator><creator>Barrios, Natalia</creator><creator>Letizia, Annalisa</creator><creator>Martín, Paloma</creator><creator>Campuzano, Sonsoles</creator><creator>Ruiz-Gómez, Mar</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110701</creationdate><title>Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate</title><author>Carrasco-Rando, Marta ; Tutor, Antonio S ; Prieto-Sánchez, Silvia ; González-Pérez, Esther ; Barrios, Natalia ; Letizia, Annalisa ; Martín, Paloma ; Campuzano, Sonsoles ; Ruiz-Gómez, Mar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c697t-2aa77d4d13f4f59c7228e19ed43ab8759e9d87eef8d9a7823a4c8b9249c5cf303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acquisitions & mergers</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Base Sequence</topic><topic>Biology</topic><topic>Cell Line</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - cytology</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Embryo, Nonmammalian - embryology</topic><topic>Embryo, Nonmammalian - metabolism</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genetic aspects</topic><topic>Genomics</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>In Situ Hybridization</topic><topic>Insects</topic><topic>Kinases</topic><topic>Microscopy, Confocal</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Muscle Development - genetics</topic><topic>Muscles - embryology</topic><topic>Muscles - metabolism</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>ras Proteins - metabolism</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Signal Transduction - genetics</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carrasco-Rando, Marta</creatorcontrib><creatorcontrib>Tutor, Antonio S</creatorcontrib><creatorcontrib>Prieto-Sánchez, Silvia</creatorcontrib><creatorcontrib>González-Pérez, Esther</creatorcontrib><creatorcontrib>Barrios, Natalia</creatorcontrib><creatorcontrib>Letizia, Annalisa</creatorcontrib><creatorcontrib>Martín, Paloma</creatorcontrib><creatorcontrib>Campuzano, Sonsoles</creatorcontrib><creatorcontrib>Ruiz-Gómez, Mar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carrasco-Rando, Marta</au><au>Tutor, Antonio S</au><au>Prieto-Sánchez, Silvia</au><au>González-Pérez, Esther</au><au>Barrios, Natalia</au><au>Letizia, Annalisa</au><au>Martín, Paloma</au><au>Campuzano, Sonsoles</au><au>Ruiz-Gómez, Mar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate</atitle><jtitle>PLoS genetics</jtitle><addtitle>PLoS Genet</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>7</volume><issue>7</issue><spage>e1002186</spage><epage>e1002186</epage><pages>e1002186-e1002186</pages><issn>1553-7404</issn><issn>1553-7390</issn><eissn>1553-7404</eissn><abstract>A central issue of myogenesis is the acquisition of identity by individual muscles. In Drosophila, at the time muscle progenitors are singled out, they already express unique combinations of muscle identity genes. This muscle code results from the integration of positional and temporal signalling inputs. Here we identify, by means of loss-of-function and ectopic expression approaches, the Iroquois Complex homeobox genes araucan and caupolican as novel muscle identity genes that confer lateral transverse muscle identity. The acquisition of this fate requires that Araucan/Caupolican repress other muscle identity genes such as slouch and vestigial. In addition, we show that Caupolican-dependent slouch expression depends on the activation state of the Ras/Mitogen Activated Protein Kinase cascade. This provides a comprehensive insight into the way Iroquois genes integrate in muscle progenitors, signalling inputs that modulate gene expression and protein activity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21811416</pmid><doi>10.1371/journal.pgen.1002186</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acquisitions & mergers Animals Animals, Genetically Modified Base Sequence Biology Cell Line Drosophila Drosophila melanogaster - cytology Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Gene expression Gene Expression Regulation, Developmental Genetic aspects Genomics Homeodomain Proteins - genetics Homeodomain Proteins - metabolism In Situ Hybridization Insects Kinases Microscopy, Confocal Mitogen-Activated Protein Kinases - metabolism Muscle Development - genetics Muscles - embryology Muscles - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Physiological aspects Proteins ras Proteins - metabolism Sequence Homology, Nucleic Acid Signal Transduction - genetics Transcription Factors - genetics Transcription Factors - metabolism Zebrafish |
| title | Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate |
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