Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging

Kidneys age at different rates, such that some people show little or no effects of aging whereas others show rapid functional decline. We sequentially used transcriptional profiling and expression quantitative trait loci (eQTL) mapping to narrow down which genes to test for association with kidney a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS genetics 2009-10, Vol.5 (10), p.e1000685-e1000685
Hauptverfasser:	Wheeler, Heather E, Metter, E Jeffrey, Tanaka, Toshiko, Absher, Devin, Higgins, John, Zahn, Jacob M, Wilhelmy, Julie, Davis, Ronald W, Singleton, Andrew, Myers, Richard M, Ferrucci, Luigi, Kim, Stuart K
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Gene Expression Profiling Gene Expression Regulation Genetic aspects Genetics Genetics and Genomics/Complex Traits Genetics and Genomics/Gene Expression Genomes Humans Hypotheses Hypothesis testing Kidney - physiology Kidney diseases Matrix Metalloproteinase 20 - genetics Physiological aspects Polymorphism, Single Nucleotide Population Prevention Quantitative Trait Loci Studies
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!