The individual blood cell telomere attrition rate is telomere length dependent

Age-associated telomere shortening is a well documented feature of peripheral blood cells in human population studies, but it is not known to what extent these data can be transferred to the individual level. Telomere length (TL) in two blood samples taken at approximately 10 years interval from 959...

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Veröffentlicht in:	PLoS genetics 2009-02, Vol.5 (2), p.e1000375-e1000375
Hauptverfasser:	Nordfjäll, Katarina, Svenson, Ulrika, Norrback, Karl-Fredrik, Adolfsson, Rolf, Lenner, Per, Roos, Göran
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Age Factors Aged Aged, 80 and over Blood Blood Cells - chemistry Blood Cells - metabolism Cancer Child Child, Preschool Chromosomes Cohort Studies Female Genetic aspects Genetics Genetics and Genomics/Cancer Genetics Genetics and Genomics/Chromosome Biology Health sciences Humans Infant Male Medical research Mens health Physiological aspects Polymerase chain reaction Public health Risk factors Studies Telomerase Telomere - chemistry Telomere - genetics Telomere - metabolism Telomeres Values Womens health Young Adult
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Zusammenfassung:	Age-associated telomere shortening is a well documented feature of peripheral blood cells in human population studies, but it is not known to what extent these data can be transferred to the individual level. Telomere length (TL) in two blood samples taken at approximately 10 years interval from 959 individuals was investigated using real-time PCR. TL was also measured in 13 families from a multigenerational cohort. As expected, we found an age-related decline in TL over time (r = -0.164, P
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1000375