Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting

Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism, whereas the status of protein metabolism is not well studied. Here, we performed comparative polysome and associated transcriptional profiling analyses to study the...

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Veröffentlicht in:	PLoS genetics 2012-08, Vol.8 (8), p.e1002902-e1002902
Hauptverfasser:	Fu, Suneng, Fan, Jason, Blanco, Joshua, Gimenez-Cassina, Alfredo, Danial, Nika N, Watkins, Steve M, Hotamisligil, Gökhan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - metabolism Biology Cholestasis - metabolism Cytochrome P450 Family 7 Development and progression Endoplasmic reticulum Endoplasmic Reticulum - metabolism Fasting Fasting - metabolism Fatty Liver - metabolism Genetic aspects Glucose - metabolism Health aspects Kinases Liver Liver - metabolism Liver - pathology Male Medicine Metabolic disorders Metabolism Mice Mice, Obese Obesity Obesity - genetics Obesity - metabolism Physiological aspects Polyribosomes - metabolism Protein Biosynthesis Specific Pathogen-Free Organisms Steroid Hydroxylases - genetics Steroid Hydroxylases - metabolism
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