Aging and chronic sun exposure cause distinct epigenetic changes in human skin
Epigenetic changes are widely considered to play an important role in aging, but experimental evidence to support this hypothesis has been scarce. We have used array-based analysis to determine genome-scale DNA methylation patterns from human skin samples and to investigate the effects of aging, chr...
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| Veröffentlicht in: | PLoS genetics 2010-05, Vol.6 (5), p.e1000971-e1000971 |
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| creator | Grönniger, Elke Weber, Barbara Heil, Oliver Peters, Nils Stäb, Franz Wenck, Horst Korn, Bernhard Winnefeld, Marc Lyko, Frank |
| description | Epigenetic changes are widely considered to play an important role in aging, but experimental evidence to support this hypothesis has been scarce. We have used array-based analysis to determine genome-scale DNA methylation patterns from human skin samples and to investigate the effects of aging, chronic sun exposure, and tissue variation. Our results reveal a high degree of tissue specificity in the methylation patterns and also showed very little interindividual variation within tissues. Data stratification by age revealed that DNA from older individuals was characterized by a specific hypermethylation pattern affecting less than 1% of the markers analyzed. Interestingly, stratification by sun exposure produced a fundamentally different pattern with a significant trend towards hypomethylation. Our results thus identify defined age-related DNA methylation changes and suggest that these alterations might contribute to the phenotypic changes associated with skin aging. |
| doi_str_mv | 10.1371/journal.pgen.1000971 |
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We have used array-based analysis to determine genome-scale DNA methylation patterns from human skin samples and to investigate the effects of aging, chronic sun exposure, and tissue variation. Our results reveal a high degree of tissue specificity in the methylation patterns and also showed very little interindividual variation within tissues. Data stratification by age revealed that DNA from older individuals was characterized by a specific hypermethylation pattern affecting less than 1% of the markers analyzed. Interestingly, stratification by sun exposure produced a fundamentally different pattern with a significant trend towards hypomethylation. Our results thus identify defined age-related DNA methylation changes and suggest that these alterations might contribute to the phenotypic changes associated with skin aging.</description><identifier>ISSN: 1553-7404</identifier><identifier>ISSN: 1553-7390</identifier><identifier>EISSN: 1553-7404</identifier><identifier>DOI: 10.1371/journal.pgen.1000971</identifier><identifier>PMID: 20523906</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aging ; Aging - genetics ; Deoxyribonucleic acid ; Dermatology/Photodermatology and Skin Aging ; Developmental Biology/Aging ; DNA ; DNA Methylation ; Epigenesis, Genetic ; Genetics ; Genetics and Genomics/Epigenetics ; Humans ; Medical research ; Molecular Biology/DNA Methylation ; Skin - metabolism ; Skin - radiation effects ; Sunlight</subject><ispartof>PLoS genetics, 2010-05, Vol.6 (5), p.e1000971-e1000971</ispartof><rights>Grönniger et al. 2010</rights><rights>2010 Grönniger et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Grönniger E, Weber B, Heil O, Peters N, Stäb F, et al. (2010) Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin. 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Our results thus identify defined age-related DNA methylation changes and suggest that these alterations might contribute to the phenotypic changes associated with skin aging.</description><subject>Adult</subject><subject>Aging</subject><subject>Aging - genetics</subject><subject>Deoxyribonucleic acid</subject><subject>Dermatology/Photodermatology and Skin Aging</subject><subject>Developmental Biology/Aging</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>Epigenesis, Genetic</subject><subject>Genetics</subject><subject>Genetics and Genomics/Epigenetics</subject><subject>Humans</subject><subject>Medical research</subject><subject>Molecular Biology/DNA Methylation</subject><subject>Skin - metabolism</subject><subject>Skin - radiation effects</subject><subject>Sunlight</subject><issn>1553-7404</issn><issn>1553-7390</issn><issn>1553-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqNUk1v1DAQtRCIloV_gMA3TrvY8Vd8QaoqCpUquMDZcpxx1kvWXuykgn9fL5tW7Y2TR543b948PYTeUrKhTNGPuzTnaMfNYYC4oYQQregzdE6FYGvFCX_-qD5Dr0rZEcJEq9VLdNYQ0TBN5Dn6djGEOGAbe-y2OcXgcJkjhj-HVOYM2Nm5AO5DmUJ0E4ZDqOtgqjC3tXGAgkPE23lvIy6_QnyNXng7FnizvCv08-rzj8uv65vvX64vL27WTkoxrblkHZfCi060vnFcaM-c0E7Y3nFlO9URzZhk3ALzylupOlC6d9C3RGtC2Qq9P_EexlTMYkUxlFEmarteukLXJ0Sf7M4cctjb_NckG8y_j5QHY3O9YwQjdKd820oAD9z21Dbc08ZK2VRPgbnK9WnZNnd7qDLilO34hPRpJ4atGdKtaVqllDiK-bAQ5PR7hjKZfSgOxtFGSHMxqhpCJGP_gWSMcqUrdoX4CelyKiWDf9BDiTkm5N4Wc0yIWRJSx949vuVh6D4S7A60xrqe</recordid><startdate>20100527</startdate><enddate>20100527</enddate><creator>Grönniger, Elke</creator><creator>Weber, Barbara</creator><creator>Heil, Oliver</creator><creator>Peters, Nils</creator><creator>Stäb, Franz</creator><creator>Wenck, Horst</creator><creator>Korn, Bernhard</creator><creator>Winnefeld, Marc</creator><creator>Lyko, Frank</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20100527</creationdate><title>Aging and chronic sun exposure cause distinct epigenetic changes in human skin</title><author>Grönniger, Elke ; 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We have used array-based analysis to determine genome-scale DNA methylation patterns from human skin samples and to investigate the effects of aging, chronic sun exposure, and tissue variation. Our results reveal a high degree of tissue specificity in the methylation patterns and also showed very little interindividual variation within tissues. Data stratification by age revealed that DNA from older individuals was characterized by a specific hypermethylation pattern affecting less than 1% of the markers analyzed. Interestingly, stratification by sun exposure produced a fundamentally different pattern with a significant trend towards hypomethylation. 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| subjects | Adult Aging Aging - genetics Deoxyribonucleic acid Dermatology/Photodermatology and Skin Aging Developmental Biology/Aging DNA DNA Methylation Epigenesis, Genetic Genetics Genetics and Genomics/Epigenetics Humans Medical research Molecular Biology/DNA Methylation Skin - metabolism Skin - radiation effects Sunlight |
| title | Aging and chronic sun exposure cause distinct epigenetic changes in human skin |
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