Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation

The study of P-element repression in Drosophila melanogaster led to the discovery of the telomeric Trans-Silencing Effect (TSE), a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin (Telomeric Associated Sequence or TAS) has the capacity to repress in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PLoS genetics 2007-09, Vol.3 (9), p.1633-1643
Hauptverfasser: Josse, Thibaut, Teysset, Laure, Todeschini, Anne-Laure, Sidor, Clara M, Anxolabéhère, Dominique, Ronsseray, Stéphane
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1643
container_issue 9
container_start_page 1633
container_title PLoS genetics
container_volume 3
creator Josse, Thibaut
Teysset, Laure
Todeschini, Anne-Laure
Sidor, Clara M
Anxolabéhère, Dominique
Ronsseray, Stéphane
description The study of P-element repression in Drosophila melanogaster led to the discovery of the telomeric Trans-Silencing Effect (TSE), a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin (Telomeric Associated Sequence or TAS) has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. TSE shows variegation among egg chambers in ovaries when silencing is incomplete. Here, we report that TSE displays an epigenetic transmission through meiosis, which involves an extrachromosomal maternally transmitted factor. We show that this silencing is highly sensitive to mutations affecting both heterochromatin formation (Su(var)205 encoding Heterochromatin Protein 1 and Su(var)3-7) and the repeat-associated small interfering RNA (or rasiRNA) silencing pathway (aubergine, homeless, armitage, and piwi). In contrast, TSE is not sensitive to mutations affecting r2d2, which is involved in the small interfering RNA (or siRNA) silencing pathway, nor is it sensitive to a mutation in loquacious, which is involved in the micro RNA (or miRNA) silencing pathway. These results, taken together with the recent discovery of TAS homologous small RNAs associated to PIWI proteins, support the proposition that TSE involves a repeat-associated small interfering RNA pathway linked to heterochromatin formation, which was co-opted by the P element to establish repression of its own transposition after its recent invasion of the D. melanogaster genome. Therefore, the study of TSE provides insight into the genetic properties of a germline-specific small RNA silencing pathway.
doi_str_mv 10.1371/journal.pgen.0030158
format Article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1313485921</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A171020174</galeid><doaj_id>oai_doaj_org_article_77a538e919f343999f4e5f5cd858a10f</doaj_id><sourcerecordid>A171020174</sourcerecordid><originalsourceid>FETCH-LOGICAL-c796t-5223c77baf701f7007c9e80c314d6f824d87e5d1f70ccf4fe3b491471f6b8a033</originalsourceid><addsrcrecordid>eNqVk2Fr1DAYx4sobk6_gWhBGPjizqRJLo0vhGOoOzg2mNO3IZc-aTPa5Ezaod_e1Kvb3fCFUkJDnt__nydP8mTZS4zmmHD87sYPwal2vq3BzREiCLPyUXaMGSMzThF9vDc_yp7FeJMgVgr-NDvCXFDMcXGc2WtofQfB6rwPysVZtC04bV39Plcuh61N9tCncIBtgBitd7n23ca6xORXF8v8TpEEVd5AD8HrJvhO9dblxodx4t3z7IlRbYQX0_8k-_rp4_XZ-Wx9-Xl1tlzPNBeLfsaKgmjON8pwhNNAXAsokSaYVgtTFrQqObBqDGltqAGyoQJTjs1iUypEyEn2eue7bX2UU5WixAQTWjJR4ESsdkTl1Y3cBtup8FN6ZeXvBR9qqUI6cguSc8VICQILQygRQhgKzDBdlaxUGJnk9WHabdh0UGlwqYztgelhxNlG1v5WYsEXhBTJ4O3OoHkgO1-u5biGEBaEseJ2TPx02iz47wPEXnY2amhb5cAPUS5KivGCigS-eQD-vQ7zHVWrdFTrjE8Z6vRV0FntHZh0s3KZHgoqEOb0PtdJkJgefvS1GmKUqy9X_8Fe_Dt7-e2QPd1jG1Bt30TfDuMTi4cg3YE6-BgDmLvqYiTHDvpTEzl2kJw6KMle7V_ovWhqGfIL1p0VwQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1313485921</pqid></control><display><type>article</type><title>Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>PubMed Central</source><creator>Josse, Thibaut ; Teysset, Laure ; Todeschini, Anne-Laure ; Sidor, Clara M ; Anxolabéhère, Dominique ; Ronsseray, Stéphane</creator><contributor>Akhtar, Asifa</contributor><creatorcontrib>Josse, Thibaut ; Teysset, Laure ; Todeschini, Anne-Laure ; Sidor, Clara M ; Anxolabéhère, Dominique ; Ronsseray, Stéphane ; Akhtar, Asifa</creatorcontrib><description>The study of P-element repression in Drosophila melanogaster led to the discovery of the telomeric Trans-Silencing Effect (TSE), a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin (Telomeric Associated Sequence or TAS) has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. TSE shows variegation among egg chambers in ovaries when silencing is incomplete. Here, we report that TSE displays an epigenetic transmission through meiosis, which involves an extrachromosomal maternally transmitted factor. We show that this silencing is highly sensitive to mutations affecting both heterochromatin formation (Su(var)205 encoding Heterochromatin Protein 1 and Su(var)3-7) and the repeat-associated small interfering RNA (or rasiRNA) silencing pathway (aubergine, homeless, armitage, and piwi). In contrast, TSE is not sensitive to mutations affecting r2d2, which is involved in the small interfering RNA (or siRNA) silencing pathway, nor is it sensitive to a mutation in loquacious, which is involved in the micro RNA (or miRNA) silencing pathway. These results, taken together with the recent discovery of TAS homologous small RNAs associated to PIWI proteins, support the proposition that TSE involves a repeat-associated small interfering RNA pathway linked to heterochromatin formation, which was co-opted by the P element to establish repression of its own transposition after its recent invasion of the D. melanogaster genome. Therefore, the study of TSE provides insight into the genetic properties of a germline-specific small RNA silencing pathway.</description><identifier>ISSN: 1553-7404</identifier><identifier>ISSN: 1553-7390</identifier><identifier>EISSN: 1553-7404</identifier><identifier>DOI: 10.1371/journal.pgen.0030158</identifier><identifier>PMID: 17941712</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Biochemistry, Molecular Biology ; Chromosomes ; DNA Transposable Elements ; Drosophila ; Drosophila melanogaster ; Epigenesis, Genetic ; Epigenetics ; Female ; Females ; Gene Silencing ; Genetics and Genomics ; Genomes ; Gonadal disorders ; Heterochromatin ; Heterochromatin - genetics ; Insects ; Life Sciences ; Molecular biology ; Mutation ; Proteins ; Risk factors ; RNA ; RNA - genetics ; RNA, Small Interfering ; Telomere ; Transgenes</subject><ispartof>PLoS genetics, 2007-09, Vol.3 (9), p.1633-1643</ispartof><rights>COPYRIGHT 2007 Public Library of Science</rights><rights>2007 Josse et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Josse T, Teysset L, Todeschini A-L, Sidor CM, Anxolabéhère D, et al. (2007) Telomeric Trans-Silencing: An Epigenetic Repression Combining RNA Silencing and Heterochromatin Formation. PLoS Genet 3(9): e158. doi:10.1371/journal.pgen.0030158</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2007 Josse et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c796t-5223c77baf701f7007c9e80c314d6f824d87e5d1f70ccf4fe3b491471f6b8a033</citedby><cites>FETCH-LOGICAL-c796t-5223c77baf701f7007c9e80c314d6f824d87e5d1f70ccf4fe3b491471f6b8a033</cites><orcidid>0000-0002-7413-1850 ; 0000-0002-9552-9577</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976332/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976332/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17941712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00193552$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Akhtar, Asifa</contributor><creatorcontrib>Josse, Thibaut</creatorcontrib><creatorcontrib>Teysset, Laure</creatorcontrib><creatorcontrib>Todeschini, Anne-Laure</creatorcontrib><creatorcontrib>Sidor, Clara M</creatorcontrib><creatorcontrib>Anxolabéhère, Dominique</creatorcontrib><creatorcontrib>Ronsseray, Stéphane</creatorcontrib><title>Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation</title><title>PLoS genetics</title><addtitle>PLoS Genet</addtitle><description>The study of P-element repression in Drosophila melanogaster led to the discovery of the telomeric Trans-Silencing Effect (TSE), a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin (Telomeric Associated Sequence or TAS) has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. TSE shows variegation among egg chambers in ovaries when silencing is incomplete. Here, we report that TSE displays an epigenetic transmission through meiosis, which involves an extrachromosomal maternally transmitted factor. We show that this silencing is highly sensitive to mutations affecting both heterochromatin formation (Su(var)205 encoding Heterochromatin Protein 1 and Su(var)3-7) and the repeat-associated small interfering RNA (or rasiRNA) silencing pathway (aubergine, homeless, armitage, and piwi). In contrast, TSE is not sensitive to mutations affecting r2d2, which is involved in the small interfering RNA (or siRNA) silencing pathway, nor is it sensitive to a mutation in loquacious, which is involved in the micro RNA (or miRNA) silencing pathway. These results, taken together with the recent discovery of TAS homologous small RNAs associated to PIWI proteins, support the proposition that TSE involves a repeat-associated small interfering RNA pathway linked to heterochromatin formation, which was co-opted by the P element to establish repression of its own transposition after its recent invasion of the D. melanogaster genome. Therefore, the study of TSE provides insight into the genetic properties of a germline-specific small RNA silencing pathway.</description><subject>Animals</subject><subject>Biochemistry, Molecular Biology</subject><subject>Chromosomes</subject><subject>DNA Transposable Elements</subject><subject>Drosophila</subject><subject>Drosophila melanogaster</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Females</subject><subject>Gene Silencing</subject><subject>Genetics and Genomics</subject><subject>Genomes</subject><subject>Gonadal disorders</subject><subject>Heterochromatin</subject><subject>Heterochromatin - genetics</subject><subject>Insects</subject><subject>Life Sciences</subject><subject>Molecular biology</subject><subject>Mutation</subject><subject>Proteins</subject><subject>Risk factors</subject><subject>RNA</subject><subject>RNA - genetics</subject><subject>RNA, Small Interfering</subject><subject>Telomere</subject><subject>Transgenes</subject><issn>1553-7404</issn><issn>1553-7390</issn><issn>1553-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqVk2Fr1DAYx4sobk6_gWhBGPjizqRJLo0vhGOoOzg2mNO3IZc-aTPa5Ezaod_e1Kvb3fCFUkJDnt__nydP8mTZS4zmmHD87sYPwal2vq3BzREiCLPyUXaMGSMzThF9vDc_yp7FeJMgVgr-NDvCXFDMcXGc2WtofQfB6rwPysVZtC04bV39Plcuh61N9tCncIBtgBitd7n23ca6xORXF8v8TpEEVd5AD8HrJvhO9dblxodx4t3z7IlRbYQX0_8k-_rp4_XZ-Wx9-Xl1tlzPNBeLfsaKgmjON8pwhNNAXAsokSaYVgtTFrQqObBqDGltqAGyoQJTjs1iUypEyEn2eue7bX2UU5WixAQTWjJR4ESsdkTl1Y3cBtup8FN6ZeXvBR9qqUI6cguSc8VICQILQygRQhgKzDBdlaxUGJnk9WHabdh0UGlwqYztgelhxNlG1v5WYsEXhBTJ4O3OoHkgO1-u5biGEBaEseJ2TPx02iz47wPEXnY2amhb5cAPUS5KivGCigS-eQD-vQ7zHVWrdFTrjE8Z6vRV0FntHZh0s3KZHgoqEOb0PtdJkJgefvS1GmKUqy9X_8Fe_Dt7-e2QPd1jG1Bt30TfDuMTi4cg3YE6-BgDmLvqYiTHDvpTEzl2kJw6KMle7V_ovWhqGfIL1p0VwQ</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Josse, Thibaut</creator><creator>Teysset, Laure</creator><creator>Todeschini, Anne-Laure</creator><creator>Sidor, Clara M</creator><creator>Anxolabéhère, Dominique</creator><creator>Ronsseray, Stéphane</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7413-1850</orcidid><orcidid>https://orcid.org/0000-0002-9552-9577</orcidid></search><sort><creationdate>20070901</creationdate><title>Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation</title><author>Josse, Thibaut ; Teysset, Laure ; Todeschini, Anne-Laure ; Sidor, Clara M ; Anxolabéhère, Dominique ; Ronsseray, Stéphane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c796t-5223c77baf701f7007c9e80c314d6f824d87e5d1f70ccf4fe3b491471f6b8a033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biochemistry, Molecular Biology</topic><topic>Chromosomes</topic><topic>DNA Transposable Elements</topic><topic>Drosophila</topic><topic>Drosophila melanogaster</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Females</topic><topic>Gene Silencing</topic><topic>Genetics and Genomics</topic><topic>Genomes</topic><topic>Gonadal disorders</topic><topic>Heterochromatin</topic><topic>Heterochromatin - genetics</topic><topic>Insects</topic><topic>Life Sciences</topic><topic>Molecular biology</topic><topic>Mutation</topic><topic>Proteins</topic><topic>Risk factors</topic><topic>RNA</topic><topic>RNA - genetics</topic><topic>RNA, Small Interfering</topic><topic>Telomere</topic><topic>Transgenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Josse, Thibaut</creatorcontrib><creatorcontrib>Teysset, Laure</creatorcontrib><creatorcontrib>Todeschini, Anne-Laure</creatorcontrib><creatorcontrib>Sidor, Clara M</creatorcontrib><creatorcontrib>Anxolabéhère, Dominique</creatorcontrib><creatorcontrib>Ronsseray, Stéphane</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Josse, Thibaut</au><au>Teysset, Laure</au><au>Todeschini, Anne-Laure</au><au>Sidor, Clara M</au><au>Anxolabéhère, Dominique</au><au>Ronsseray, Stéphane</au><au>Akhtar, Asifa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation</atitle><jtitle>PLoS genetics</jtitle><addtitle>PLoS Genet</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>3</volume><issue>9</issue><spage>1633</spage><epage>1643</epage><pages>1633-1643</pages><issn>1553-7404</issn><issn>1553-7390</issn><eissn>1553-7404</eissn><abstract>The study of P-element repression in Drosophila melanogaster led to the discovery of the telomeric Trans-Silencing Effect (TSE), a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin (Telomeric Associated Sequence or TAS) has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. TSE shows variegation among egg chambers in ovaries when silencing is incomplete. Here, we report that TSE displays an epigenetic transmission through meiosis, which involves an extrachromosomal maternally transmitted factor. We show that this silencing is highly sensitive to mutations affecting both heterochromatin formation (Su(var)205 encoding Heterochromatin Protein 1 and Su(var)3-7) and the repeat-associated small interfering RNA (or rasiRNA) silencing pathway (aubergine, homeless, armitage, and piwi). In contrast, TSE is not sensitive to mutations affecting r2d2, which is involved in the small interfering RNA (or siRNA) silencing pathway, nor is it sensitive to a mutation in loquacious, which is involved in the micro RNA (or miRNA) silencing pathway. These results, taken together with the recent discovery of TAS homologous small RNAs associated to PIWI proteins, support the proposition that TSE involves a repeat-associated small interfering RNA pathway linked to heterochromatin formation, which was co-opted by the P element to establish repression of its own transposition after its recent invasion of the D. melanogaster genome. Therefore, the study of TSE provides insight into the genetic properties of a germline-specific small RNA silencing pathway.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>17941712</pmid><doi>10.1371/journal.pgen.0030158</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-7413-1850</orcidid><orcidid>https://orcid.org/0000-0002-9552-9577</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1553-7404
ispartof PLoS genetics, 2007-09, Vol.3 (9), p.1633-1643
issn 1553-7404
1553-7390
1553-7404
language eng
recordid cdi_plos_journals_1313485921
source MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central
subjects Animals
Biochemistry, Molecular Biology
Chromosomes
DNA Transposable Elements
Drosophila
Drosophila melanogaster
Epigenesis, Genetic
Epigenetics
Female
Females
Gene Silencing
Genetics and Genomics
Genomes
Gonadal disorders
Heterochromatin
Heterochromatin - genetics
Insects
Life Sciences
Molecular biology
Mutation
Proteins
Risk factors
RNA
RNA - genetics
RNA, Small Interfering
Telomere
Transgenes
title Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T12%3A58%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Telomeric%20trans-silencing:%20an%20epigenetic%20repression%20combining%20RNA%20silencing%20and%20heterochromatin%20formation&rft.jtitle=PLoS%20genetics&rft.au=Josse,%20Thibaut&rft.date=2007-09-01&rft.volume=3&rft.issue=9&rft.spage=1633&rft.epage=1643&rft.pages=1633-1643&rft.issn=1553-7404&rft.eissn=1553-7404&rft_id=info:doi/10.1371/journal.pgen.0030158&rft_dat=%3Cgale_plos_%3EA171020174%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1313485921&rft_id=info:pmid/17941712&rft_galeid=A171020174&rft_doaj_id=oai_doaj_org_article_77a538e919f343999f4e5f5cd858a10f&rfr_iscdi=true