CTG trinucleotide repeat "big jumps": large expansions, small mice

Trinucleotide repeat expansions are the genetic cause of numerous human diseases, including fragile X mental retardation, Huntington disease, and myotonic dystrophy type 1. Disease severity and age of onset are critically linked to expansion size. Previous mouse models of repeat instability have not...

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Veröffentlicht in:	PLoS genetics 2007-04, Vol.3 (4), p.e52-e52
Hauptverfasser:	Gomes-Pereira, Mário, Foiry, Laurent, Nicole, Annie, Huguet, Aline, Junien, Claudine, Munnich, Arnold, Gourdon, Geneviève
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alleles Animals Base Sequence Body Size - genetics Causes of Deoxyribonucleic acid Disease DNA Genetic disorders Genetics Genetics and Genomics Genomic Instability - genetics Glutamate Homozygote Humans Mental retardation Mice Mice, Inbred C57BL Mice, Transgenic Molecular Biology Mus (Mouse) Mutation Myotonic dystrophy Neurological Disorders Neuromuscular diseases Pathogenesis RNA Splicing - genetics Rodents Trinucleotide Repeat Expansion - genetics Trinucleotide repeats
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