The Eps8/IRSp53/VASP network differentially controls actin capping and bundling in filopodia formation

There is a body of literature that describes the geometry and the physics of filopodia using either stochastic models or partial differential equations and elasticity and coarse-grained theory. Comparatively, there is a paucity of models focusing on the regulation of the network of proteins that con...

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Veröffentlicht in:	PLoS computational biology 2011-07, Vol.7 (7), p.e1002088-e1002088
Hauptverfasser:	Vaggi, Federico, Disanza, Andrea, Milanesi, Francesca, Di Fiore, Pier Paolo, Menna, Elisabetta, Matteoli, Michela, Gov, Nir S, Scita, Giorgio, Ciliberto, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - metabolism Actins - metabolism Adaptor Proteins, Signal Transducing Behavior Biology Cell adhesion & migration Cell Adhesion Molecules - metabolism Cells Experiments Filopodia HeLa Cells Hippocampus - cytology Histocytochemistry Humans Immunoblotting Intracellular Signaling Peptides and Proteins - metabolism Metabolic Networks and Pathways - physiology Microfilament Proteins - metabolism Models, Biological Nerve Tissue Proteins - metabolism Neurons Neurons - metabolism Ordinary differential equations Partial differential equations Phosphoproteins - metabolism Physiological aspects Proteins Pseudopodia - metabolism Reproducibility of Results Sensitivity analysis Signal Transduction - physiology Stochastic models
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