A variant of TNFR2-Fc fusion protein exhibits improved efficacy in treating experimental rheumatoid arthritis

Etanercept, a TNF receptor 2-Fc fusion protein, is currently being used for the treatment of rheumatoid arthritis (RA). However, 25% to 38% of patients show no response which is suspected to be partially due to insufficient affinity of this protein to TNFalpha. By using computational protein design,...

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Veröffentlicht in:	PLoS computational biology 2010-02, Vol.6 (2), p.e1000669-e1000669
Hauptverfasser:	Yang, Tong, Wang, Zheng, Wu, Fang, Tan, Jingwei, Shen, Yijun, Li, Erguang, Dai, Jingzhi, Shen, Ronghai, Li, Gang, Wu, Jinsong, Wang, Luochun, Wang, Haibo, Liu, Yanjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Experimental - drug therapy Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Biochemistry/Biomacromolecule-Ligand Interactions Biotechnology/Protein Chemistry and Proteomics Care and treatment Cell Line Cell Survival - physiology Collagen Computational Biology - methods Computational Biology/Macromolecular Structure Analysis Computational Biology/Protein Structure Prediction Crystal structure Diagnosis Dosage and administration Etanercept Genetic aspects Histocytochemistry Immunoglobulin G - genetics Immunoglobulin G - metabolism Immunoglobulin G - pharmacology Immunoglobulin G - therapeutic use Laboratory animals Ligands Mice Mutation Pharmaceuticals Pharmacology/Drug Development Properties Protein Binding Proteins Rats Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism Receptors, Tumor Necrosis Factor - therapeutic use Rheumatoid arthritis Rheumatology/Autoimmunity, Autoimmune, and Inflammatory Diseases Rheumatology/Rheumatoid Arthritis Surface Plasmon Resonance Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism
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