A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants

Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed with monotherapy of an HCV protease inhibitor, telaprevir. Variant fitness was est...

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Veröffentlicht in:	PLoS computational biology 2010-04, Vol.6 (4), p.e1000745-e1000745
Hauptverfasser:	Adiwijaya, Bambang S, Herrmann, Eva, Hare, Brian, Kieffer, Tara, Lin, Chao, Kwong, Ann D, Garg, Varun, Randle, John C R, Sarrazin, Christoph, Zeuzem, Stefan, Caron, Paul R
Format:	Artikel
Sprache:	eng
Schlagworte:	Computational Biology/Evolutionary Modeling Computational Biology/Systems Biology Computer Simulation Diagnosis Dosage and administration Drug Resistance, Viral - genetics Drug therapy Evolution Evolution, Molecular Fitness (Genetics) Genetic Fitness Genetic variation Genotype & phenotype Hepacivirus - drug effects Hepacivirus - genetics Hepatitis Hepatitis C Hepatitis C - virology HIV Human immunodeficiency virus Humans Identification and classification Models, Biological Multivariate Analysis Mutation Oligopeptides - pharmacology Patients Pharmaceuticals Pharmacology/Drug Development Pharmacology/Drug Resistance Pharmacology/Personalized Medicine Plasma Protease inhibitors Protease Inhibitors - pharmacology Random variables RNA, Viral Viral Load Virology Virology/Antivirals, including Modes of Action and Resistance Virology/New Therapies, including Antivirals and Immunotherapy Virology/Persistence and Latency
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