Redundancy and the evolution of cis-regulatory element multiplicity

The promoter regions of many genes contain multiple binding sites for the same transcription factor (TF). One possibility is that this multiplicity evolved through transitional forms showing redundant cis-regulation. To evaluate this hypothesis, we must disentangle the relative contributions of diff...

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Veröffentlicht in:	PLoS computational biology 2010-07, Vol.6 (7), p.e1000848-e1000848
Hauptverfasser:	Paixão, Tiago, Azevedo, Ricardo B R
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cluster Analysis Computational Biology/Evolutionary Modeling Computational Biology/Population Genetics Computational Biology/Transcriptional Regulation Evolution Evolution, Molecular Evolutionary Biology/Bioinformatics Evolutionary Biology/Genomics Gene expression Gene Expression Regulation, Fungal - genetics Genetic aspects Genetics Genome, Fungal Insects Mathematical models Models, Genetic Models, Statistical Mutation Physiological aspects Promoters (Genetics) Protein Binding Recombination, Genetic Regulatory Elements, Transcriptional - genetics Transcription factors Transcription Factors - metabolism Yeast Yeasts - genetics
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