Dynamics and potential impact of the immune response to chronic myelogenous leukemia

Recent mathematical models have been developed to study the dynamics of chronic myelogenous leukemia (CML) under imatinib treatment. None of these models incorporates the anti-leukemia immune response. Recent experimental data show that imatinib treatment may promote the development of anti-leukemia...

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Veröffentlicht in:	PLoS computational biology 2008-06, Vol.4 (6), p.e1000095-e1000095
Hauptverfasser:	Kim, Peter S, Lee, Peter P, Levy, Doron
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides Cancer Cell division Chronic myeloid leukemia Computer Simulation Drug therapy Health aspects Humans Hypotheses Imatinib Mesylate Immune response Immune system Immunity, Innate - immunology Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Lymphocytes Mathematical models Mathematics Models, Immunological Oncology/Hematological Malignancies Patient outcomes Patients Piperazines - administration & dosage Pyrimidines - administration & dosage Scholarships & fellowships T-Lymphocytes - drug effects T-Lymphocytes - immunology Transplants & implants
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