Toward a detailed description of the thermally induced dynamics of the core promoter

Establishing the general and promoter-specific mechanistic features of gene transcription initiation requires improved understanding of the sequence-dependent structural/dynamic features of promoter DNA. Experimental data suggest that a spontaneous dsDNA strand separation at the transcriptional star...

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Veröffentlicht in:	PLoS computational biology 2009-03, Vol.5 (3), p.e1000313-e1000313
Hauptverfasser:	Alexandrov, Boian S, Gelev, Vladimir, Yoo, Sang Wook, Bishop, Alan R, Rasmussen, Kim Ø, Usheva, Anny
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence BASIC BIOLOGICAL SCIENCES Biochemistry & Molecular Biology Computational Biology/Transcriptional Regulation Computer Simulation Deoxyribonucleic acid DNA DNA - chemistry DNA - ultrastructure DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - ultrastructure Enzymes Experiments Genetics Hot Temperature Mathematical & Computational Biology Models, Chemical Models, Genetic Models, Molecular Molecular Sequence Data Phase transitions Promoter Regions, Genetic RNA polymerase Sequence Analysis, DNA - methods
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