Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities

The dose response curve is the gold standard for measuring the effect of a drug treatment, but is rarely used in genomic scale transcriptional profiling due to perceived obstacles of cost and analysis. One barrier to examining transcriptional dose responses is that existing methods for microarray da...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS computational biology 2009-09, Vol.5 (9), p.e1000512
Hauptverfasser:	Ji, Rui-Ru, de Silva, Heshani, Jin, Yisheng, Bruccoleri, Robert E, Cao, Jian, He, Aiqing, Huang, Wenjun, Kayne, Paul S, Neuhaus, Isaac M, Ott, Karl-Heinz, Penhallow, Becky, Cockett, Mark I, Neubauer, Michael G, Siemers, Nathan O, Ross-Macdonald, Petra
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Automation Benzamides - pharmacology Biochemistry/Drug Discovery Biological assays Biotechnology/Chemical Biology of the Cell Cancer Care and treatment Cell cycle Cell Cycle - drug effects Cell Line Cluster Analysis Computational Biology - methods Computational Biology/Systems Biology Criminal investigation Dasatinib Diphenylamine - analogs & derivatives Diphenylamine - pharmacology Dose-Response Relationship, Drug Drug dosages Experiments Gene Expression - drug effects Gene Expression Profiling - methods Gene loci Genetics and Genomics/Gene Expression Humans Imatinib Mesylate Methods Molecular Biology/Bioinformatics Oligonucleotide Array Sequence Analysis - methods Pharmacology/Drug Development Piperazines - pharmacology Protein Kinase Inhibitors - pharmacology Pyrimidines - pharmacology Signal Transduction - drug effects Thiazoles - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!