Spontaneous reaction silencing in metabolic optimization

Metabolic reactions of single-cell organisms are routinely observed to become dispensable or even incapable of carrying activity under certain circumstances. Yet, the mechanisms as well as the range of conditions and phenotypes associated with this behavior remain very poorly understood. Here we pre...

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Veröffentlicht in:	PLoS computational biology 2008-12, Vol.4 (12), p.e1000236-e1000236
Hauptverfasser:	Nishikawa, Takashi, Gulbahce, Natali, Motter, Adilson E
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Bacteria - genetics Bacteria - growth & development Bacteria - metabolism Behavior Biochemical Phenomena - genetics Biochemical Phenomena - physiology Biological Evolution Computational Biology - methods Computational Biology/Metabolic Networks Computational Biology/Systems Biology Computer Simulation E coli Environment Environmental conditions Escherichia coli Escherichia coli - genetics Escherichia coli - growth & development Escherichia coli - metabolism Evolution & development Growth rate Helicobacter pylori Metabolic Networks and Pathways - genetics Metabolic Networks and Pathways - physiology Metabolites Methods Models, Biological Organisms Saccharomyces cerevisiae Staphylococcus aureus Studies
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