Transient calcium and dopamine increase PKA activity and DARPP-32 phosphorylation

Reinforcement learning theorizes that strengthening of synaptic connections in medium spiny neurons of the striatum occurs when glutamatergic input (from cortex) and dopaminergic input (from substantia nigra) are received simultaneously. Subsequent to learning, medium spiny neurons with strengthened...

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Veröffentlicht in:	PLoS computational biology 2006-09, Vol.2 (9), p.e119-e119
Hauptverfasser:	Lindskog, Maria, Kim, MyungSook, Wikström, Martin A, Blackwell, Kim T, Kotaleski, Jeanette Hellgren
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine 3'-5'-monophosphate-regulated phosphoprotein adenylyl-cyclase Analysis Animal Behavior bidirectional synaptic plasticity Bioinformatics - Computational Biology Calcium Calcium - metabolism camp-regulated phosphoprotein Cell Biology Computational Biology Computer Simulation Cyclic AMP-Dependent Protein Kinases - metabolism Cyclin-dependent kinases dependent protein-kinase Differential equations Dopamine Dopamine - metabolism Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism Experiments Kinases long-term potentiation Mammals Medicin och hälsovetenskap medium spiny neurons Models, Biological Neurology Neurons Neuroscience nucleus-accumbens neurons Ordinary differential equations Phosphorylation Phosphothreonine - metabolism Plasticity Protein Binding Protein kinases Proteins receptor stimulation increases Second Messenger Systems striatal projection neurons Systems Biology
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