P38 MAP kinase signaling is required for the conversion of CD4+CD25- T cells into iTreg

CD4+CD25+ regulatory T cells (Treg) are important mediators of immune tolerance. A subset of Treg can be generated in the periphery by TGF-beta dependent conversion of conventional CD4+CD25- T cells into induced Treg (iTreg). In chronic viral infection or malignancy, such induced iTreg, which limit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2008-10, Vol.3 (10), p.e3302-e3302
Hauptverfasser:	Huber, Samuel, Schrader, Jörg, Fritz, Gerhard, Presser, Katrin, Schmitt, Steffen, Waisman, Ari, Lüth, Stefan, Blessing, Manfred, Herkel, Johannes, Schramm, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Animals Blotting, Western Bone morphogenetic proteins Cancer CD25 antigen CD4 antigen CD4 Antigens - immunology Cell activation Chronic infection Conversion Cytokines Flow Cytometry Foxp3 protein Health aspects Immunity Immunoglobulins Immunological tolerance Immunology Immunology/Autoimmunity Immunology/Immunomodulation Immunology/Leukocyte Signaling and Gene Expression Immunoregulation Inflammatory diseases Inhibition Interleukin-2 Receptor alpha Subunit - immunology Kinases Lymphocytes Lymphocytes T Malignancy MAP kinase Mice p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Proteins Signal Transduction T cells T-Lymphocytes, Regulatory - immunology Target recognition Transforming growth factor-b Transforming growth factors Trends
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!