PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

Parkinson's disease (PD) is a common age-related neurodegenerative disease and it is critical to develop models which recapitulate the pathogenic process including the effect of the ageing process. Although the pathogenesis of sporadic PD is unknown, the identification of the mendelian genetic...

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Veröffentlicht in:	PloS one 2008-06, Vol.3 (6), p.e2455-e2455
Hauptverfasser:	Wood-Kaczmar, Alison, Gandhi, Sonia, Yao, Zhi, Abramov, Andrey Y, Abramov, Andrey S Y, Miljan, Erik A, Keen, Gregory, Stanyer, Lee, Hargreaves, Iain, Klupsch, Kristina, Deas, Emma, Downward, Julian, Mansfield, Louise, Jat, Parmjit, Taylor, Joanne, Heales, Simon, Duchen, Michael R, Latchman, David, Tabrizi, Sarah J, Wood, Nicholas W
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animal models Animals Apoptosis Blotting, Western Cell survival Cell Survival - physiology Cells, Cultured Degeneration Development and progression DNA, Complementary Dopamine - metabolism Dopamine receptors Drosophila Electrophoresis, Polyacrylamide Gel Genetic engineering Humans Kinases Lysosomes Mammals Mesencephalon Mice Microscopy, Electron, Transmission Microscopy, Fluorescence Mitochondria Mitochondria - physiology Mitochondrial DNA Movement disorders Mutation Nervous system diseases Neurodegeneration Neurodegenerative diseases Neurological Disorders/Movement Disorders Neurological Disorders/Neurogenetics Neurons Neurons - metabolism Neurons - physiology Neuroprotection Neuroscience/Neuronal and Glial Cell Biology Neuroscience/Neuronal Signaling Mechanisms Oxidative stress Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson's disease Pathogenesis Protein Kinases - physiology PTEN-induced putative kinase Reverse Transcriptase Polymerase Chain Reaction RNA-mediated interference Staurosporine Stem cell transplantation Stem cells Substantia nigra Viability
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