Genome sequence of Brucella abortus vaccine strain S19 compared to virulent strains yields candidate virulence genes

The Brucella abortus strain S19, a spontaneously attenuated strain, has been used as a vaccine strain in vaccination of cattle against brucellosis for six decades. Despite many studies, the physiological and molecular mechanisms causing the attenuation are not known. We have applied pyrosequencing t...

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Veröffentlicht in:	PloS one 2008-05, Vol.3 (5), p.e2193-e2193
Hauptverfasser:	Crasta, Oswald R, Folkerts, Otto, Fei, Zhangjun, Mane, Shrinivasrao P, Evans, Clive, Martino-Catt, Susan, Bricker, Betsy, Yu, GongXin, Du, Lei, Sobral, Bruno W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal vaccines Animals Attenuation Bacterial Vaccines Bioinformatics Brucella Brucella abortus Brucella abortus - genetics Brucella abortus - pathogenicity Brucella melitensis Brucellosis Cattle Chromosomes Chromosomes, Bacterial Comparative analysis Computational Biology Computational Biology/Comparative Sequence Analysis Computational Biology/Genomics Endoplasmic reticulum Erythritol Gene sequencing Genes Genetic aspects Genetics and Genomics Genetics and Genomics/Bioinformatics Genetics and Genomics/Comparative Genomics Genetics and Genomics/Genomics Genome, Bacterial Genomes Genomics Identification Infections Infectious Diseases Infectious Diseases/Bacterial Infections Life sciences Membrane proteins Metabolism Molecular modelling Nucleotide sequence Open Reading Frames Proteins Species Specificity Vaccination Vaccines Virulence Virulence (Microbiology) Virulence - genetics Virulence factors
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