Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study

Epigenetic changes are emerging as one of the most important events in carcinogenesis. Two alterations in the pattern of DNA methylation in breast cancer (BC) have been previously reported; active estrogen receptor-alpha (ER-alpha) is associated with decreased methylation of ER-alpha target (ERT) ge...

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Veröffentlicht in:	PloS one 2008-07, Vol.3 (7), p.e2656-e2656
Hauptverfasser:	Widschwendter, Martin, Apostolidou, Sophia, Raum, Elke, Rothenbacher, Dietrich, Fiegl, Heidi, Menon, Usha, Stegmaier, Christa, Jacobs, Ian J, Brenner, Hermann
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological activity Blood Blood cells Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - genetics Cancer Cancer genetics Cancer research Carcinogenesis Carcinogens Case-Control Studies Chronic diseases Confidence intervals Deoxyribonucleic acid Development and progression DNA DNA - metabolism DNA Methylation Epidemiology Epigenesis, Genetic Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Female Gene Expression Regulation, Neoplastic Gene loci Genes Genetic research Genetics Genetics and Genomics/Epigenetics Genomes Genotype Glial cell line-derived neurotrophic factor Health aspects Health risk assessment Health risks Hormone replacement therapy Humans Invasiveness Mesenchyme Methylation Middle Aged Oncology/Breast Cancer Peripheral blood Polycomb group proteins Predictions Public Health and Epidemiology/Preventive Medicine Regression Analysis Repressor Proteins - metabolism Risk Risk Factors Saccharomyces cerevisiae Stem cells Women's Health/Breast Cancer Women's Health/Menopause and Post-Reproductive Women's Health Womens health
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