Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system

Genome-wide identification of mRNAs regulated by RNA-binding proteins is crucial to uncover post-transcriptional gene regulatory systems. The conserved PUF family RNA-binding proteins repress gene expression post-transcriptionally by binding to sequence elements in 3'-UTRs of mRNAs. Despite the...

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Veröffentlicht in:	PloS one 2008-09, Vol.3 (9), p.e3164-e3164
Hauptverfasser:	Galgano, Alessia, Forrer, Michael, Jaskiewicz, Lukasz, Kanitz, Alexander, Zavolan, Mihaela, Gerber, André P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Angiogenesis Animals Binding proteins Binding Sites Bioinformatics Caenorhabditis elegans Cell Biology/Gene Expression Comparative analysis Computational Biology/Sequence Motif Analysis Conservation Conserved sequence Cytokines Data analysis Deoxyribonucleic acid DNA DNA microarrays DNA Primers - chemistry Drosophila melanogaster Drosophila melanogaster - metabolism Enrichment Fibroblasts Gene expression Gene Expression Regulation Gene sequencing Genetic aspects Genetics and Genomics/Bioinformatics Genetics and Genomics/Genomics Genomes Genomics HeLa Cells Humans Insects Kinases Messages Messenger RNA MicroRNA MicroRNAs miRNA Multigene Family Neurogenesis Nucleotide sequence Pharmaceutical sciences Physiology Post-transcription Protein Binding Proteins Ribonucleic acid RNA RNA, Messenger - metabolism RNA-binding protein RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism Saccharomyces cerevisiae Signal transduction Stem cells Transcription Transcription (Genetics) Transcription factors Trends Vascular endothelial growth factor Yeast
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