Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice

Pre-existing immunity to human adenovirus serotype 5 (Ad5) is common in the general population. Bypassing pre-existing immunity could maximize Ad5 vaccine efficacy. Vaccination by the intramuscular (I.M.), nasal (I.N.) or oral (P.O.) route with Ad5 expressing Ebola Zaire glycoprotein (Ad5-ZGP) fully...

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Veröffentlicht in:	PloS one 2008-10, Vol.3 (10), p.e3548-e3548
Hauptverfasser:	Croyle, Maria A, Patel, Ami, Tran, Kaylie N, Gray, Michael, Zhang, Yi, Strong, James E, Feldmann, Heinz, Kobinger, Gary P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - immunology Adenoviruses Administration, Intranasal Animals Antibodies Antibody Formation - physiology Antigens Avian flu Botulism Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - immunology CD8 antigen Cytomegalovirus Deoxyribonucleic acid Dilution Disease susceptibility DNA Drug delivery systems Drug Delivery Systems - methods Ebola Vaccines - administration & dosage Ebola Vaccines - immunology Ebola virus Ebolavirus Ebolavirus - immunology Encephalitis Genomes Glycoproteins Hemorrhagic Fever, Ebola - immunology Hemorrhagic Fever, Ebola - pathology Hemorrhagic Fever, Ebola - veterinary Immune response Immune system Immunity Immunity (Disease) Immunity, Mucosal - drug effects Immunity, Mucosal - physiology Immunization Immunoglobulins Immunology Immunotherapy, Active - methods Infections Infectious Diseases/Viral Infections Interferon Laboratories Lymphocytes Lymphocytes B Lymphocytes T Mice Mice, Inbred C57BL Nervous system Pathogens Polyethylene glycol Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Proteins Public health Rabies Survival Analysis T cells Vaccination Vaccine efficacy Vaccines Virology Virosomes - immunology Viruses γ-Interferon
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