Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration

Variants in the complement cascade genes and the LOC387715/HTRA1, have been widely reported to associate with age-related macular degeneration (AMD), the most common cause of visual impairment in industrialized countries. We investigated the association between the LOC387715 A69S and complement comp...

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Veröffentlicht in:	PloS one 2008-12, Vol.3 (12), p.e3833-e3833
Hauptverfasser:	Seitsonen, Sanna P, Onkamo, Päivi, Peng, Gang, Xiong, Momiao, Tommila, Petri V, Ranta, Päivi H, Holopainen, Juha M, Moilanen, Jukka A, Palosaari, Tapani, Kaarniranta, Kai, Meri, Seppo, Immonen, Ilkka R, Järvelä, Irma E
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age related diseases Alleles Analysis Blood Blood & organ donations Blood donation Cigarettes Complement Complement component C3 Complement factor H Complement Factor H - genetics Disease susceptibility Genes Genetic Predisposition to Disease Genetics Genetics and Genomics/Complex Traits Genetics and Genomics/Medical Genetics Genotype Genotypes Humans Life sciences Loci Logistic Models Macular degeneration Macular Degeneration - genetics Medical records Ophthalmology/Macular Disorders Ophthalmology/Retinal Disorders Patients People with disabilities Physiological aspects Polymorphism, Single Nucleotide - genetics Population genetics Proteins - genetics Proteomics Regression models Risk Risk Factors Smoking
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