Design and construction of a double inversion recombination switch for heritable sequential genetic memory

Inversion recombination elements present unique opportunities for computing and information encoding in biological systems. They provide distinct binary states that are encoded into the DNA sequence itself, allowing us to overcome limitations posed by other biological memory or logic gate systems. F...

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Veröffentlicht in:	PloS one 2008-07, Vol.3 (7), p.e2815-e2815
Hauptverfasser:	Ham, Timothy S, Lee, Sung K, Keasling, Jay D, Arkin, Adam P
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Bacterial Proteins - genetics BASIC BIOLOGICAL SCIENCES Binary systems (materials) Bioengineering Biotechnology/Applied Microbiology Biotechnology/Bioengineering Blood substitutes Cell death Chromosome Inversion Cloning Computational Biology - methods Computer memory Deoxyribonucleic acid DNA DNA - metabolism DNA recombination DNA sequencing E coli electrical circuits Escherichia coli Escherichia coli - metabolism Evolution Feasibility studies Gene expression Genes, Bacterial Genetic Engineering Genetic Techniques Information storage Information systems Integrases - genetics Inversion Laboratories Lactose Logic logic circuits Models, Biological Models, Genetic Models, Statistical Molecular Biology/Recombination Nucleotide sequence polymerase chain reaction Proteins recombinant proteins Recombinase Recombinases Recombination recombination reactions Recombination, Genetic Salmonella Salmonella Typhimurium Synthetic biology synthetic genetic network Transcription factors
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