Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases

Anthrax edema toxin (EdTx) is an adenylate cyclase which operates in the perinuclear region of host cells. However, the action of EdTx is poorly understood, especially at molecular level. The ability of EdTx to modulate cAMP-dependent signaling was studied in Jurkat T cells and was compared with tha...

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Veröffentlicht in:	PloS one 2008-10, Vol.3 (10), p.e3564-e3564
Hauptverfasser:	Puhar, Andrea, Dal Molin, Federica, Horvath, Stéphanie, Ladant, Daniel, Ladants, Daniel, Montecucco, Cesare
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase Adenylyl Cyclases - pharmacology Anthrax Antibiotics Antigens Antigens, Bacterial Apoptosis Bacterial Toxins Catalysis Cell activation Cell adhesion & migration Cell Biology/Cell Signaling Cholera Cholera toxin Chromatin Colforsin - pharmacology Crosslinking Cues Cyclic adenosine monophosphate Cyclic AMP - metabolism Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Dose-Response Relationship, Drug Edema Enzyme Activation - drug effects Forskolin Gene expression Genes, Reporter - drug effects Humans Infections Infectious Diseases/Bacterial Infections Intoxication Jurkat Cells Kinases Localization Lymphocytes Lymphocytes T Microbiology/Cellular Microbiology and Pathogenesis Mitogens Nuclear transport Pathogens Pertussis Phosphorylation Phosphorylation - drug effects Plasmids Protein binding Protein Binding - drug effects Protein kinase A Protein kinases Protein transport Proteins Pseudomonas aeruginosa Public health Reporter gene Response Elements - drug effects Ribosomal protein S6 kinase Signal Transduction - drug effects Substrate Specificity T cell receptors T cells T-cell receptor Time Factors Transcription activation Transcriptional Activation - drug effects Translocation Water-borne diseases Waterborne diseases Whooping cough
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