Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate

Chronic myeloid leukemia (CML) is characterized by the presence of a constitutively active Abl kinase, which is the product of a chimeric BCR-ABL gene, caused by the genetic translocation known as the Philadelphia chromosome. Imatinib, a selective inhibitor of the Bcr-Abl tyrosine kinase, has signif...

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Veröffentlicht in:	PloS one 2008-10, Vol.3 (10), p.e3593
Hauptverfasser:	Chou, C James, O'Hare, Thomas, Lefebvre, Sophie, Alvarez, David, Tyner, Jeffrey W, Eide, Christopher A, Druker, Brian J, Gottesfeld, Joel M
Format:	Artikel
Sprache:	eng
Schlagworte:	Abl protein Animal models Animals Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Agents, Alkylating - pharmacology Base Sequence - drug effects BCR protein BCR-ABL protein Benzamides Biochemistry/Drug Discovery Blood Cells - metabolism Blood Cells - pathology Bone Marrow Cells - metabolism Bone Marrow Cells - physiology Cancer Cell cycle Cell Proliferation - drug effects Cells, Cultured Chemical Biology/Small Molecule Chemistry Chlorambucil Chlorambucil - administration & dosage Chlorambucil - chemistry Chlorambucil - pharmacology Chromosomes Chronic lymphocytic leukemia Chronic myeloid leukemia Deoxyribonucleic acid DNA DNA sequencing Drug dosages Drug Evaluation, Preclinical Drug resistance Experiments Fusion protein Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - metabolism Gene expression Growth Hematology Hodgkin's disease Humans Imatinib Imatinib Mesylate Imidazole Immunological tolerance Inhibitors Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Lymphatic leukemia Lymphocytes Lymphocytes B Medical prognosis Mice Models, Biological Molecular biology Mutation Myeloid leukemia Non-Hodgkin's lymphoma Nucleotide sequence Nylons - chemistry Nylons - pharmacology Oncology Oncology/Myeloproliferative Disorders, including Chronic Myeloid Leukemia Patients Philadelphia chromosome Piperazines - administration & dosage Piperazines - pharmacology Polyamides Protein-tyrosine kinase Pyrimidines - administration & dosage Pyrimidines - pharmacology Remission Science Substrate Specificity - drug effects Toxicity Transduction, Genetic Translocation Tumors Tyrosine
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