Oncologic trogocytosis of an original stromal cells induces chemoresistance of ovarian tumours
The microenvironment plays a major role in the onset and progression of metastasis. Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneal cavity where interactions within the microenvironment might lead to chemoresistance. Mesothelial cells are important actors of the peritoneal hom...
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| Veröffentlicht in: | PloS one 2008-12, Vol.3 (12), p.e3894 |
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| creator | Rafii, Arash Mirshahi, Pejman Poupot, Mary Faussat, Anne-Marie Simon, Anne Ducros, Elodie Mery, Eliane Couderc, Bettina Lis, Raphael Capdet, Jerome Bergalet, Julie Querleu, Denis Dagonnet, Francoise Fournié, Jean-Jacques Marie, Jean-Pierre Pujade-Lauraine, Eric Favre, Gilles Soria, Jeanine Mirshahi, Massoud |
| description | The microenvironment plays a major role in the onset and progression of metastasis. Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneal cavity where interactions within the microenvironment might lead to chemoresistance. Mesothelial cells are important actors of the peritoneal homeostasis; we determined their role in the acquisition of chemoresistance of ovarian tumours.
We isolated an original type of stromal cells, referred to as "Hospicells" from ascitis of patients with ovarian carcinosis using limiting dilution. We studied their ability to confer chemoresistance through heterocellular interactions. These stromal cells displayed a new phenotype with positive immunostaining for CD9, CD10, CD29, CD146, CD166 and Multi drug resistance protein. They preferentially interacted with epithelial ovarian cancer cells. This interaction induced chemoresistance to platin and taxans with the implication of multi-drug resistance proteins. This contact enabled EOC cells to capture patches of the Hospicells membrane through oncologic trogocytosis, therefore acquiring their functional P-gp proteins and thus developing chemoresistance. Presence of Hospicells on ovarian cancer tissue micro-array from patients with neo-adjuvant chemotherapy was also significantly associated to chemoresistance.
This is the first report of trogocytosis occurring between a cancer cell and an original type of stromal cell. This interaction induced autonomous acquisition of chemoresistance. The presence of stromal cells within patient's tumour might be predictive of chemoresistance. The specific interaction between cancer cells and stromal cells might be targeted during chemotherapy. |
| doi_str_mv | 10.1371/journal.pone.0003894 |
| format | Article |
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We isolated an original type of stromal cells, referred to as "Hospicells" from ascitis of patients with ovarian carcinosis using limiting dilution. We studied their ability to confer chemoresistance through heterocellular interactions. These stromal cells displayed a new phenotype with positive immunostaining for CD9, CD10, CD29, CD146, CD166 and Multi drug resistance protein. They preferentially interacted with epithelial ovarian cancer cells. This interaction induced chemoresistance to platin and taxans with the implication of multi-drug resistance proteins. This contact enabled EOC cells to capture patches of the Hospicells membrane through oncologic trogocytosis, therefore acquiring their functional P-gp proteins and thus developing chemoresistance. Presence of Hospicells on ovarian cancer tissue micro-array from patients with neo-adjuvant chemotherapy was also significantly associated to chemoresistance.
This is the first report of trogocytosis occurring between a cancer cell and an original type of stromal cell. This interaction induced autonomous acquisition of chemoresistance. The presence of stromal cells within patient's tumour might be predictive of chemoresistance. The specific interaction between cancer cells and stromal cells might be targeted during chemotherapy.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0003894</identifier><identifier>PMID: 19079610</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Actors ; Aged ; B cells ; Biological Assay ; Cancer ; Cancer metastasis ; CD29 antigen ; CD9 antigen ; Cell Adhesion ; Cell adhesion & migration ; Cell Biology ; Cell Biology/Cell Adhesion ; Cell Biology/Cellular Death and Stress Responses ; Cell Communication ; Cell Line, Tumor ; Cell Separation ; Chemoresistance ; Chemotherapy ; Claudius ; Colorectal cancer ; Cytotoxicity ; Development and progression ; Dilution ; Drug resistance ; Drug Resistance, Neoplasm ; Endothelium ; Epithelium - pathology ; Epithelium - ultrastructure ; Female ; Genotype & phenotype ; Growth factors ; Hematology ; Homeostasis ; Human health and pathology ; Humans ; Intracellular Membranes - metabolism ; Life Sciences ; Lymphocytes ; Lymphoma ; Medical research ; Melanoma ; Metastases ; Metastasis ; Middle Aged ; Multidrug resistance ; Multidrug Resistance-Associated Proteins - metabolism ; Oncology/Gynecological Cancers ; Ovarian cancer ; Ovarian carcinoma ; Ovarian Neoplasms - drug therapy ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - ultrastructure ; Patients ; Peritoneum ; Pharmacology/Drug Resistance ; Phenotype ; Phenotypes ; Plasma membranes ; Proteins ; Stem cells ; Stromal cells ; Stromal Cells - pathology ; Stromal Cells - ultrastructure ; Tumors ; Women's Health/Gynecological Cancers</subject><ispartof>PloS one, 2008-12, Vol.3 (12), p.e3894</ispartof><rights>COPYRIGHT 2008 Public Library of Science</rights><rights>2008 Rafii Tabrizi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Rafii Tabrizi et al. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c699t-e6d694d6a5a0f35859fa50a7739b6a6a0dc80f2f307a516fd3147166c66d829a3</citedby><cites>FETCH-LOGICAL-c699t-e6d694d6a5a0f35859fa50a7739b6a6a0dc80f2f307a516fd3147166c66d829a3</cites><orcidid>0000-0002-4530-5508 ; 0000-0001-6542-6908 ; 0000-0002-2688-1091 ; 0000-0002-2344-1883</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597737/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597737/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19079610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-02472253$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Cordes, Nils</contributor><creatorcontrib>Rafii, Arash</creatorcontrib><creatorcontrib>Mirshahi, Pejman</creatorcontrib><creatorcontrib>Poupot, Mary</creatorcontrib><creatorcontrib>Faussat, Anne-Marie</creatorcontrib><creatorcontrib>Simon, Anne</creatorcontrib><creatorcontrib>Ducros, Elodie</creatorcontrib><creatorcontrib>Mery, Eliane</creatorcontrib><creatorcontrib>Couderc, Bettina</creatorcontrib><creatorcontrib>Lis, Raphael</creatorcontrib><creatorcontrib>Capdet, Jerome</creatorcontrib><creatorcontrib>Bergalet, Julie</creatorcontrib><creatorcontrib>Querleu, Denis</creatorcontrib><creatorcontrib>Dagonnet, Francoise</creatorcontrib><creatorcontrib>Fournié, Jean-Jacques</creatorcontrib><creatorcontrib>Marie, Jean-Pierre</creatorcontrib><creatorcontrib>Pujade-Lauraine, Eric</creatorcontrib><creatorcontrib>Favre, Gilles</creatorcontrib><creatorcontrib>Soria, Jeanine</creatorcontrib><creatorcontrib>Mirshahi, Massoud</creatorcontrib><title>Oncologic trogocytosis of an original stromal cells induces chemoresistance of ovarian tumours</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The microenvironment plays a major role in the onset and progression of metastasis. Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneal cavity where interactions within the microenvironment might lead to chemoresistance. Mesothelial cells are important actors of the peritoneal homeostasis; we determined their role in the acquisition of chemoresistance of ovarian tumours.
We isolated an original type of stromal cells, referred to as "Hospicells" from ascitis of patients with ovarian carcinosis using limiting dilution. We studied their ability to confer chemoresistance through heterocellular interactions. These stromal cells displayed a new phenotype with positive immunostaining for CD9, CD10, CD29, CD146, CD166 and Multi drug resistance protein. They preferentially interacted with epithelial ovarian cancer cells. This interaction induced chemoresistance to platin and taxans with the implication of multi-drug resistance proteins. This contact enabled EOC cells to capture patches of the Hospicells membrane through oncologic trogocytosis, therefore acquiring their functional P-gp proteins and thus developing chemoresistance. Presence of Hospicells on ovarian cancer tissue micro-array from patients with neo-adjuvant chemotherapy was also significantly associated to chemoresistance.
This is the first report of trogocytosis occurring between a cancer cell and an original type of stromal cell. This interaction induced autonomous acquisition of chemoresistance. The presence of stromal cells within patient's tumour might be predictive of chemoresistance. The specific interaction between cancer cells and stromal cells might be targeted during chemotherapy.</description><subject>Actors</subject><subject>Aged</subject><subject>B cells</subject><subject>Biological Assay</subject><subject>Cancer</subject><subject>Cancer metastasis</subject><subject>CD29 antigen</subject><subject>CD9 antigen</subject><subject>Cell Adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell Biology</subject><subject>Cell Biology/Cell Adhesion</subject><subject>Cell Biology/Cellular Death and Stress Responses</subject><subject>Cell Communication</subject><subject>Cell Line, Tumor</subject><subject>Cell Separation</subject><subject>Chemoresistance</subject><subject>Chemotherapy</subject><subject>Claudius</subject><subject>Colorectal cancer</subject><subject>Cytotoxicity</subject><subject>Development and progression</subject><subject>Dilution</subject><subject>Drug resistance</subject><subject>Drug Resistance, Neoplasm</subject><subject>Endothelium</subject><subject>Epithelium - pathology</subject><subject>Epithelium - ultrastructure</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Growth factors</subject><subject>Hematology</subject><subject>Homeostasis</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Intracellular Membranes - metabolism</subject><subject>Life Sciences</subject><subject>Lymphocytes</subject><subject>Lymphoma</subject><subject>Medical research</subject><subject>Melanoma</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Multidrug resistance</subject><subject>Multidrug Resistance-Associated Proteins - metabolism</subject><subject>Oncology/Gynecological Cancers</subject><subject>Ovarian cancer</subject><subject>Ovarian carcinoma</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - ultrastructure</subject><subject>Patients</subject><subject>Peritoneum</subject><subject>Pharmacology/Drug Resistance</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Plasma membranes</subject><subject>Proteins</subject><subject>Stem cells</subject><subject>Stromal cells</subject><subject>Stromal Cells - pathology</subject><subject>Stromal Cells - ultrastructure</subject><subject>Tumors</subject><subject>Women's Health/Gynecological 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USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rafii, Arash</au><au>Mirshahi, Pejman</au><au>Poupot, Mary</au><au>Faussat, Anne-Marie</au><au>Simon, Anne</au><au>Ducros, Elodie</au><au>Mery, Eliane</au><au>Couderc, Bettina</au><au>Lis, Raphael</au><au>Capdet, Jerome</au><au>Bergalet, Julie</au><au>Querleu, Denis</au><au>Dagonnet, Francoise</au><au>Fournié, Jean-Jacques</au><au>Marie, Jean-Pierre</au><au>Pujade-Lauraine, Eric</au><au>Favre, Gilles</au><au>Soria, Jeanine</au><au>Mirshahi, Massoud</au><au>Cordes, Nils</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oncologic trogocytosis of an original stromal cells induces chemoresistance of ovarian tumours</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2008-12-16</date><risdate>2008</risdate><volume>3</volume><issue>12</issue><spage>e3894</spage><pages>e3894-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The microenvironment plays a major role in the onset and progression of metastasis. Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneal cavity where interactions within the microenvironment might lead to chemoresistance. Mesothelial cells are important actors of the peritoneal homeostasis; we determined their role in the acquisition of chemoresistance of ovarian tumours.
We isolated an original type of stromal cells, referred to as "Hospicells" from ascitis of patients with ovarian carcinosis using limiting dilution. We studied their ability to confer chemoresistance through heterocellular interactions. These stromal cells displayed a new phenotype with positive immunostaining for CD9, CD10, CD29, CD146, CD166 and Multi drug resistance protein. They preferentially interacted with epithelial ovarian cancer cells. This interaction induced chemoresistance to platin and taxans with the implication of multi-drug resistance proteins. This contact enabled EOC cells to capture patches of the Hospicells membrane through oncologic trogocytosis, therefore acquiring their functional P-gp proteins and thus developing chemoresistance. Presence of Hospicells on ovarian cancer tissue micro-array from patients with neo-adjuvant chemotherapy was also significantly associated to chemoresistance.
This is the first report of trogocytosis occurring between a cancer cell and an original type of stromal cell. This interaction induced autonomous acquisition of chemoresistance. The presence of stromal cells within patient's tumour might be predictive of chemoresistance. The specific interaction between cancer cells and stromal cells might be targeted during chemotherapy.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19079610</pmid><doi>10.1371/journal.pone.0003894</doi><tpages>e3894</tpages><orcidid>https://orcid.org/0000-0002-4530-5508</orcidid><orcidid>https://orcid.org/0000-0001-6542-6908</orcidid><orcidid>https://orcid.org/0000-0002-2688-1091</orcidid><orcidid>https://orcid.org/0000-0002-2344-1883</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2008-12, Vol.3 (12), p.e3894 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1312320881 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Actors Aged B cells Biological Assay Cancer Cancer metastasis CD29 antigen CD9 antigen Cell Adhesion Cell adhesion & migration Cell Biology Cell Biology/Cell Adhesion Cell Biology/Cellular Death and Stress Responses Cell Communication Cell Line, Tumor Cell Separation Chemoresistance Chemotherapy Claudius Colorectal cancer Cytotoxicity Development and progression Dilution Drug resistance Drug Resistance, Neoplasm Endothelium Epithelium - pathology Epithelium - ultrastructure Female Genotype & phenotype Growth factors Hematology Homeostasis Human health and pathology Humans Intracellular Membranes - metabolism Life Sciences Lymphocytes Lymphoma Medical research Melanoma Metastases Metastasis Middle Aged Multidrug resistance Multidrug Resistance-Associated Proteins - metabolism Oncology/Gynecological Cancers Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Ovarian Neoplasms - ultrastructure Patients Peritoneum Pharmacology/Drug Resistance Phenotype Phenotypes Plasma membranes Proteins Stem cells Stromal cells Stromal Cells - pathology Stromal Cells - ultrastructure Tumors Women's Health/Gynecological Cancers |
| title | Oncologic trogocytosis of an original stromal cells induces chemoresistance of ovarian tumours |
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