Effective gene therapy in a mouse model of prion diseases

Classical drug therapies against prion diseases have encountered serious difficulties. It has become urgent to develop radically different therapeutic strategies. Previously, we showed that VSV-G pseudotyped FIV derived vectors carrying dominant negative mutants of the PrP gene are efficient to inhi...

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Veröffentlicht in:	PloS one 2008-07, Vol.3 (7), p.e2773-e2773
Hauptverfasser:	Toupet, Karine, Compan, Valérie, Crozet, Carole, Mourton-Gilles, Chantal, Mestre-Francés, Nadine, Ibos, Françoise, Corbeau, Pierre, Verdier, Jean-Michel, Perrier, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Astrocytes - cytology Brain Brain - pathology Brain diseases Brain research Cell culture Disease Disease Models, Animal Diseases Feline immunodeficiency virus Gene therapy Genetic Therapy - methods Gliosis Health aspects House mouse Humans Immunoglobulins Immunology Implantation Infectious Diseases/Prion Diseases Injections Kinases Lentivirus - genetics Life Sciences Life span Medical materials Medical treatment Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mutants Neurobiology Neurological Disorders/Prion Diseases Neurons Neurons and Cognition Polymorphism, Genetic Prion diseases Prion Diseases - genetics Prion Diseases - therapy Prion protein Prions Prions - metabolism Prolongation Proteins PrPC Proteins - metabolism Surgical implants Time Factors Tubes Vectors (Biology) Viral Envelope Proteins - metabolism Viral genetics Virions Virology/New Therapies, including Antivirals and Immunotherapy
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