The marine-derived oligosaccharide sulfate (MdOS), a novel multiple tyrosine kinase inhibitor, combats tumor angiogenesis both in vitro and in vivo

Despite the emerging success of multi-targeted protein tyrosine kinase (PTK) inhibitors in cancer therapy, significant side effects and resistance concerns seems to be avoided unlikely. The aim of the present study was to identify novel multi-targeting PTK inhibitors. The kinase enzymatic activities...

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Veröffentlicht in:	PloS one 2008-11, Vol.3 (11), p.e3774-e3774
Hauptverfasser:	Ma, Jingui, Xin, Xianliang, Meng, Linghua, Tong, Linjiang, Lin, Liping, Geng, Meiyu, Ding, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Analysis Angiogenesis Animals Aorta Aorta - metabolism Assaying ATP Binding c-Kit protein Cancer Cancer therapies Cancer treatment Cell Biology/Cell Signaling Cell growth Cell Line, Tumor Chickens Chorioallantoic membrane Chorioallantoic Membrane - metabolism Endothelial cells Endothelium, Vascular - metabolism Enzymatic activity Enzyme inhibitors Enzyme-linked immunosorbent assay Enzymes Epidermal growth factor Epidermal growth factor receptors ErbB-2 protein Extracellular signal-regulated kinase Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 2 Health aspects Humans In Vitro Techniques Inhibitors Kinases Kinetics Laboratories Ligands Lung cancer Microcirculation Microvasculature Mutation Neoplasms - drug therapy Neoplasms - metabolism Neovascularization Neovascularization, Pathologic Oligosaccharides - chemistry Oncology/Oncology Agents Pharmacology Pharmacology/Drug Development Phenols (Class of compounds) Phosphorylation Phosphotransferases Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein-tyrosine kinase Protein-Tyrosine Kinases - antagonists & inhibitors Proteins Rats Rats, Sprague-Dawley Rodents Side effects Signal transduction Simulation Src protein Sulfates Sulfates - chemistry Sulforhodamine Surface plasmon resonance Therapy Tumors Tyrosine Tyrosine kinase inhibitors Vascular endothelial growth factor Vascular endothelial growth factor receptors Vascularization
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