Inducing cross-clade neutralizing antibodies against HIV-1 by immunofocusing

Although vaccines are important in preventing viral infections by inducing neutralizing antibodies (nAbs), HIV-1 has proven to be a difficult target and escapes humoral immunity through various mechanisms. We sought to test whether HIV-1 Env mimics may serve as immunogens. Using random peptide phage...

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Veröffentlicht in:	PloS one 2008-12, Vol.3 (12), p.e3937-e3937
Hauptverfasser:	Humbert, Michael, Rasmussen, Robert A, Ong, Helena, Kaiser, Fabian M P, Hu, Shiu-Lok, Ruprecht, Ruth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS vaccines Amino Acid Sequence Amino acids Animals Antibodies Antigenic determinants B cells Blood Specimen Collection Blotting, Western C-Terminus Cancer Computer applications Cross Reactions - immunology Dendritic cells Deoxyribonucleic acid DNA env Gene Products, Human Immunodeficiency Virus - chemistry env Gene Products, Human Immunodeficiency Virus - immunology Enzyme-Linked Immunosorbent Assay Epitopes Epitopes - chemistry Epitopes - immunology Female Glycoprotein gp120 Glycoprotein gp160 Glycoproteins Health aspects HIV HIV Antibodies - immunology HIV Antibodies - isolation & purification HIV tests HIV-1 - classification HIV-1 - immunology Homology Human immunodeficiency virus Human immunodeficiency virus 1 Humoral immunity Immune Sera Immune system Immunity Immunogenicity Immunoglobulins Immunology Infection Infections Infectious Diseases Inhibitory Concentration 50 Inserts Macaca mulatta Mice Mice, Inbred BALB C Models, Molecular Molecular Mimicry Molecular Sequence Data Monkeys Neutralization Tests - methods Neutralizing Peptide Library Peptides Phage display Phages Polyclonal antibodies Protein Conformation Proteins Recombinant Fusion Proteins - immunology Simian/human immunodeficiency virus Species Specificity Vaccination Vaccines Virology Viruses
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