Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinase

Legionella pneumophila, is an intracellular pathogen that causes Legionnaires' disease in humans, a potentially lethal pneumonia. L. pneumophila has the ability to enter and replicate in the host and is essential for pathogenesis. Phagocytosis was measured by cell invasion assays. Construction...

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Veröffentlicht in:	PloS one 2008-10, Vol.3 (10), p.e3324-e3324
Hauptverfasser:	Tachado, Souvenir D, Samrakandi, Mustapha M, Cirillo, Jeffrey D
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acanthamoeba castellanii AKT protein Animals Antigens Bacteria Bacterial infections Cell activation Cell Line Chromatography Cloning Drug dosages E coli Enzyme Activation Enzyme Inhibitors - pharmacology Escherichia coli Health aspects Immunology/Cellular Microbiology and Pathogenesis Immunology/Immune Response Immunology/Immunity to Infections Immunology/Immunomodulation Immunology/Innate Immunity Infections Kinases Legionella Legionella pneumophila Legionella pneumophila - immunology Legionnaire's disease Legionnaires disease Legionnaires' disease bacterium Lipid kinase Lipids Macrophages Macrophages - immunology Medicine Mice Pathogenesis Phagocytosis Phosphatase Phosphates Phosphatidylinositol 3,4,5-triphosphate Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol 3-phosphate Phospholipids Phosphorylation Pneumonia Polymerase Chain Reaction Polymerization Protein kinases Protein-serine/threonine kinase Proteins Proto-Oncogene Proteins c-akt - metabolism Signal transduction Thin layer chromatography Threonine Tyrosine Virulence (Microbiology) Wortmannin
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