Enhanced proliferation of monolayer cultures of embryonic stem (ES) cell-derived cardiomyocytes following acute loss of retinoblastoma

Cardiomyocyte (CM) cell cycle analysis has been impeded because of a reliance on primary neonatal cultures of poorly proliferating cells or chronic transgenic animal models with innate compensatory mechanisms. We describe an in vitro model consisting of monolayer cultures of highly proliferative emb...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2008-12, Vol.3 (12), p.e3896-e3896
Hauptverfasser:	Yamanaka, Satoshi, Zahanich, Ihor, Wersto, Robert P, Boheler, Kenneth R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Analysis Animal genetic engineering Animal models Animals Apoptosis Apoptosis - drug effects Ascorbic acid Atrial natriuretic peptide Calcium binding proteins Calsequestrin Cancer Cardiomyocytes Cell Biology/Cell Growth and Division Cell Biology/Developmental Molecular Mechanisms Cell cycle Cell Line Cell Proliferation - drug effects Cell Separation Cultivation Developmental Biology/Cell Differentiation Drug Resistance, Microbial Electrophysiological Phenomena Embryonic Stem Cells - cytology Embryonic Stem Cells - drug effects Fibroblasts G1 Phase - drug effects Genes Genetically modified animals Heart Heart cells Heart diseases Ischemia Kinases Laboratories Maturation Membrane potential Microscopy Monolayers Monomolecular films Musculoskeletal system MYB protein Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Narcotics Natriuretic peptides Neonates Physiology/Cardiovascular Physiology and Circulation Proteins Puromycin Puromycin - pharmacology Rats Rattus norvegicus Retina Retinoblastoma Retinoblastoma Protein - deficiency Retinoblastoma Protein - metabolism Rodents S Phase - drug effects Smooth muscle Sodium-Calcium Exchanger - metabolism Stem cells Studies Transcription factors Transgenic animals Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!