Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity

The androgen receptor (AR) is a steroid-activated transcription factor that binds at specific DNA locations and plays a key role in the etiology of prostate cancer. While numerous studies have identified a clear connection between AR binding and expression of target genes for a limited number of loc...

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Veröffentlicht in:	PloS one 2008-11, Vol.3 (11), p.e3645-e3645
Hauptverfasser:	Jia, Li, Berman, Benjamin P, Jariwala, Unnati, Yan, Xiting, Cogan, Jon P, Walters, Allison, Chen, Ting, Buchanan, Grant, Frenkel, Baruch, Coetzee, Gerhard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Acetylation Analysis Androgen receptors Androgens B cells Binding sites Biochemistry/Transcription and Translation Cancer Cell Line, Tumor Chromatin Chromatin Immunoprecipitation Chromosomes, Human, Pair 19 - genetics Chromosomes, Human, Pair 20 - genetics Deoxyribonucleic acid Development and progression DNA DNA microarrays Epigenetics Etiology Gene expression Genes Genetic aspects Genetics and Genomics Genome, Human Histone H3 Histones - metabolism Humans Immunoprecipitation Loci Male Models, Biological Molecular Biology/Chromatin Structure Molecular Biology/Histone Modification Nuclear factor I Physiological aspects Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Receptors, Androgen - genetics Receptors, Androgen - metabolism Response Elements - genetics siRNA Transcription (Genetics) Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
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