Plasma gelsolin depletion and circulating actin in sepsis: a pilot study

Depletion of the circulating actin-binding protein, plasma gelsolin (pGSN) has been described in septic patients and animals. We hypothesized that the extent of pGSN reduction correlates with outcomes of septic patients and that circulating actin is a manifestation of sepsis. We assayed pGSN in plas...

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Veröffentlicht in:	PloS one 2008-11, Vol.3 (11), p.e3712-e3712
Hauptverfasser:	Lee, Po-Shun, Patel, Sanjay R, Christiani, David C, Bajwa, Ednan, Stossel, Thomas P, Waxman, Aaron B
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - blood APACHE Binding proteins Critical care Critical Care and Emergency Medicine Critical Care and Emergency Medicine/Sepsis and Multiple Organ Failure Depletion Gelsolin Gelsolin - blood Health aspects Hospitals Hostages Humans Hyperoxia Immunology/Cellular Microbiology and Pathogenesis Infection Intensive care Intensive care units Medical research Medical schools Mortality Multiple organ dysfunction syndrome Muscle proteins Patients Pilot Projects Plasmas (physics) Protein binding Proteins Reduction Rodents Sepsis Sepsis - blood Sepsis - complications Sepsis - mortality Surgery Survival Rate Tissues Trauma Womens health
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