The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy

Hypertrophic (HCM) and dilated (DCM) cardiomyopathies result from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2). We determined whether TNNT2 mutations cause cardiomyopathies by altering cTnT function or quantity; whether the severity of DCM is related to the ratio of mutan...

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Veröffentlicht in:	PloS one 2008-07, Vol.3 (7), p.e2642-e2642
Hauptverfasser:	Ahmad, Ferhaan, Banerjee, Sanjay K, Lage, Michele L, Huang, Xueyin N, Smith, Stephen H, Saba, Samir, Rager, Jennifer, Conner, David A, Janczewski, Andrzej M, Tobita, Kimimasa, Tinney, Joseph P, Moskowitz, Ivan P, Perez-Atayde, Antonio R, Keller, Bradley B, Mathier, Michael A, Shroff, Sanjeev G, Seidman, Christine E, Seidman, J G
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Bioengineering Calcium Calcium-binding protein Cardiac arrhythmia Cardiomyocytes Cardiomyopathy Cardiomyopathy, Dilated - genetics Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Hypertrophic - metabolism Cardiovascular Disorders/Arrhythmias, Electrophysiology, and Pacing Cardiovascular Disorders/Heart Failure Cardiovascular Disorders/Myopathies Children & youth Desensitization Dilated cardiomyopathy Echocardiography Embryo, Mammalian - metabolism Embryos Eutrophication Genes Genetics and Genomics/Disease Models Genetics and Genomics/Genetics of Disease Heart Heart - embryology Heart diseases Heart failure Histology Hospitals Medical schools Medicine Mice Mice, Knockout Mice, Transgenic Muscle contraction Mutants Mutation Myocardium - metabolism Pathology Pediatrics Phenotype Proteins Rodents Sarcomeres Transcription Transgenes Transgenic mice Troponin Troponin T Troponin T - genetics Troponin T - metabolism Troponin T - physiology Tumor necrosis factor-TNF Ventricle
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