Control of bone mass and remodeling by PTH receptor signaling in osteocytes

Osteocytes, former osteoblasts buried within bone, are thought to orchestrate skeletal adaptation to mechanical stimuli. However, it remains unknown whether hormones control skeletal homeostasis through actions on osteocytes. Parathyroid hormone (PTH) stimulates bone remodeling and may cause bone lo...

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Veröffentlicht in:	PloS one 2008-08, Vol.3 (8), p.e2942-e2942
Hauptverfasser:	O'Brien, Charles A, Plotkin, Lilian I, Galli, Carlo, Goellner, Joseph J, Gortazar, Arancha R, Allen, Matthew R, Robling, Alexander G, Bouxsein, Mary, Schipani, Ernestina, Turner, Charles H, Jilka, Robert L, Weinstein, Robert S, Manolagas, Stavros C, Bellido, Teresita
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biocompatibility Biology Bone and Bones - anatomy & histology Bone and Bones - physiology Bone density Bone diseases Bone growth Bone loss Bone marrow Bone mass Bone remodeling Bone Remodeling - physiology Bone resorption Bone surgery Cell Biology/Cell Signaling Diabetes and Endocrinology/Bone and Mineral Metabolism Diabetes and Endocrinology/Endocrinology Endocrinology Extracellular Matrix Proteins - genetics Gene expression Genetic engineering Homeostasis Hormones Humans Kinases Ligands Low density lipoprotein LRP5 protein Mechanical stimuli Metabolism Mice Mice, Transgenic Osteoblasts Osteoblasts - cytology Osteoclasts - cytology Osteocytes Osteocytes - physiology Osteoporosis Parathyroid Parathyroid hormone Parathyroid hormones Phosphoproteins - genetics Physiology/Cell Signaling Physiology/Endocrinology Physiology/Integrative Physiology Proteins Receptor, Parathyroid Hormone, Type 1 - genetics Receptors, Parathyroid Hormone - physiology Signal Transduction - physiology SOST protein Transgenic mice Wnt protein
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