Genetic variability of hepatitis C virus before and after combined therapy of interferon plus ribavirin

We present an analysis of the selective forces acting on two hepatitis C virus genome regions previously postulated to be involved in the viral response to combined antiviral therapy. One includes the three hypervariable regions in the envelope E2 glycoprotein, and the other encompasses the PKR bind...

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Veröffentlicht in:	PloS one 2008-08, Vol.3 (8), p.e3058
Hauptverfasser:	Cuevas, José Manuel, Torres-Puente, Manuela, Jiménez-Hernández, Nuria, Bracho, María Alma, García-Robles, Inmaculada, Wrobel, Boris, Carnicer, Fernando, del Olmo, Juan, Ortega, Enrique, Moya, Andrés, González-Candelas, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Amino acids Analysis Antiviral agents Antiviral Agents - therapeutic use Biological evolution Biological response modifiers Complementarity Determining Regions - drug effects Evolution, Molecular Evolutionary Biology/Bioinformatics Evolutionary Biology/Evolutionary and Comparative Genetics Genetic variability Genetic Variation - drug effects Genetics Genetics and Genomics/Population Genetics Genome, Viral - drug effects Genomes Genomics Glycoproteins Hepacivirus - drug effects Hepacivirus - genetics Hepatitis Hepatitis C Hepatitis C - drug therapy Hepatitis C virus Humans Immune system Integrated software Interferon Interferon alpha-2 Interferon-alpha - therapeutic use Kinases Patients Phylogenetics Phylogeny Proteins Recombinant Proteins Ribavirin Ribavirin - therapeutic use Therapy Viral Nonstructural Proteins - drug effects Viral Nonstructural Proteins - genetics Virology/Antivirals, including Modes of Action and Resistance Virology/Immune Evasion Virology/Virus Evolution and Symbiosis Viruses α-Interferon
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