A novel strategy involved in [corrected] anti-oxidative defense: the conversion of NADH into NADPH by a metabolic network

The reduced nicotinamide adenine dinucleotide phosphate (NADPH) is pivotal to the cellular anti-oxidative defence strategies in most organisms. Although its production mediated by different enzyme systems has been relatively well-studied, metabolic networks dedicated to the biogenesis of NADPH have...

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Veröffentlicht in:	PloS one 2008-07, Vol.3 (7), p.e2682-e2682
Hauptverfasser:	Singh, Ranji, Lemire, Joseph, Mailloux, Ryan J, Appanna, Vasu D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - chemistry Biochemistry Biosynthesis Cell Biology/Microbial Physiology and Metabolism Cellular manufacture Conversion Defense mechanisms Dehydrogenases Deoxyribonucleic acid DNA Electrophoresis, Gel, Two-Dimensional Electrophoresis, Polyacrylamide Gel Enzymes Hypoxia Isocitrate lyase Kinases Malate dehydrogenase Malate synthase Malic enzyme Menadione Metabolic networks Metabolic Networks and Pathways Metabolism Microbiology/Microbial Physiology and Metabolism Mitochondria Models, Biological NAD - chemistry NADH NADP NADP - chemistry NADPH-diaphorase Niacinamide Nicotinamide Nicotinamide adenine dinucleotide Oxaloacetates - chemistry Oxidants - chemistry Oxidation-Reduction Oxidative Stress Oxidizing agents Phosphates Proteins Pseudomonas fluorescens Pseudomonas fluorescens - enzymology Pseudomonas fluorescens - metabolism Pyruvate carboxylase Pyruvate kinase Pyruvate Kinase - biosynthesis Pyruvic acid Ribonucleotide reductase Subcellular Fractions - metabolism Transformation Vitamin K 3 - chemistry
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