Phase 1 trial of AMA1-C1/Alhydrogel plus CPG 7909: an asexual blood-stage vaccine for Plasmodium falciparum malaria

Apical Membrane Antigen 1 (AMA1), a polymorphic merozoite surface protein, is a leading blood-stage malaria vaccine candidate. This is the first reported use in humans of an investigational vaccine, AMA1-C1/Alhydrogel, with the novel adjuvant CPG 7909. A phase 1 trial was conducted at the University...

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Veröffentlicht in:	PloS one 2008-08, Vol.3 (8), p.e2940-e2940
Hauptverfasser:	Mullen, Gregory E D, Ellis, Ruth D, Miura, Kazutoyo, Malkin, Elissa, Nolan, Caroline, Hay, Mhorag, Fay, Michael P, Saul, Allan, Zhu, Daming, Rausch, Kelly, Moretz, Samuel, Zhou, Hong, Long, Carole A, Miller, Louis H, Treanor, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aluminum Hydroxide - toxicity Animals Antigens Antigens, Protozoan - immunology Antigens, Protozoan - toxicity Apical membrane antigen 1 Blood Clinical trials CpG islands Drug dosages Enzyme-linked immunosorbent assay Enzymes Hepatitis Homology Humans Immune serum Immunogenicity Immunoglobulin G Immunology/Immune Response Infectious diseases Infectious Diseases/Neglected Tropical Diseases Infectious Diseases/Protozoal Infections Infertility Influenza Inhibition Malaria Malaria vaccines Malaria Vaccines - toxicity Malaria, Falciparum - immunology Medical research Membrane Proteins - immunology Membrane Proteins - toxicity Middle Aged Mortality Oligodeoxyribonucleotides - toxicity Parasites Pathogenesis Plasmodium falciparum Plasmodium falciparum - immunology Polycystic ovary syndrome Product development Protozoan Proteins - immunology Protozoan Proteins - toxicity Review boards Safety Studies Vaccination Vaccines Vector-borne diseases
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