Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance

Ghrelin may influence the development of obesity through its role in the control of energy balance, food intake, and regulation of body weight. The effects of ghrelin are mediated via the growth hormone secretagogue receptor (GHSR). We genotyped 7 single nucleotide polymorphisms (SNPs) in the GHSR g...

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Veröffentlicht in:	PloS one 2008-08, Vol.3 (8), p.e2941-e2941
Hauptverfasser:	Mager, Ursula, Degenhardt, Tatjana, Pulkkinen, Leena, Kolehmainen, Marjukka, Tolppanen, Anna-Maija, Lindström, Jaana, Eriksson, Johan G, Carlberg, Carsten, Tuomilehto, Jaakko, Uusitupa, Matti
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Binding sites Biochemistry Body mass index Body weight Body Weight - genetics Body weight loss Chronic illnesses Diabetes Diabetes and Endocrinology/Obesity Diabetes mellitus Disease control Disease prevention Energy balance Food Food intake Gene expression Genes Genetic aspects Genetic disorders Genetic Variation Genetics and Genomics/Genetics of Disease Genomes Ghrelin Glucose Glucose - metabolism Glucose Intolerance - genetics Glucose tolerance Growth hormone Growth hormones Haplotypes Health promotion Humans Insulin Life Style Lifestyles Medical research Metabolism Molecular Biology Neurological disorders Nutrition research Obesity Obesity - genetics Overweight Phenotype Physiological aspects Polymorphism, Genetic Population studies Prevention Primary care Protein Binding Proteins Public health Receptors, Ghrelin - genetics Receptors, Ghrelin - metabolism Rodents Signaling Single nucleotide polymorphisms Single-nucleotide polymorphism Somatotropin Studies Tumors Type 2 diabetes Weight control Weight Loss - genetics
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