Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease

It has become generally accepted that new neurones are added and integrated mainly in two areas of the mammalian CNS, the subventricular zone and the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus, which is of central importance in learning and memory. The newly generated cells...

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Veröffentlicht in:	PloS one 2008-08, Vol.3 (8), p.e2935-e2935
Hauptverfasser:	Rodríguez, José J, Jones, Victoria C, Tabuchi, Masashi, Allan, Stuart M, Knight, Elysse M, LaFerla, Frank M, Oddo, Salvatore, Verkhratsky, Alexei
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Age Aging - genetics Alzheimer Disease - pathology Alzheimer's disease Amino Acid Substitution Amyloid beta-protein Amyloid precursor protein Animal cognition Animals Behavior Brain Central nervous system Cognitive ability Dementia disorders Dentate gyrus Dentate Gyrus - growth & development Dentate Gyrus - pathology Disease Models, Animal DNA repair Female Females Genetic engineering Glial fibrillary acidic protein Hippocampus Histone H3 Humans Immunohistochemistry Impairment Learning Life sciences Male Mammals Memory Mice Mice, Transgenic Mutation Neurobiology Neurodegenerative diseases Neurogenesis Neurological Disorders/Alzheimer Disease Neurological Disorders/Cognitive Neurology and Dementia Neurons Neuroscience Neuroscience/Neurobiology of Disease and Regeneration Neurosciences Prenatal development Presenilin 1 Presenilins - genetics Reduction Rodents Senile plaques Serum Amyloid A Protein - genetics Studies Subventricular zone Tau protein tau Proteins - genetics Transgenic mice β-Amyloid
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