HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation

Infection by the human immunodeficiency virus (HIV) is characterized by functional impairment and chronic activation of T lymphocytes, the causes of which are largely unexplained. We cultured peripheral blood mononuclear cells (PBMC) from HIV-uninfected donors in the presence or absence of HIV. HIV...

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Veröffentlicht in:	PloS one 2008-08, Vol.3 (8), p.e2961-e2961
Hauptverfasser:	Boasso, Adriano, Hardy, Andrew W, Anderson, Stephanie A, Dolan, Matthew J, Shearer, Gene M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome ADP-ribosyl Cyclase 1 - biosynthesis AIDS Antigens, CD - biosynthesis Antigens, Differentiation, T-Lymphocyte - biosynthesis B cells Biological response modifiers Catabolism CD28 antigen CD38 antigen CD4 antigen CD69 antigen CD8 antigen Cell activation Cell cycle Cell proliferation Dendritic cells Dendritic Cells - immunology Dendritic Cells - virology Development and progression Dioxygenase Health aspects HIV HIV infections HIV Infections - immunology HIV Infections - metabolism HIV patients HIV-1 Human immunodeficiency virus Humans Immunology/Immunity to Infections Immunology/Immunomodulation Immunology/Innate Immunity Immunology/Leukocyte Activation Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Infection Infections Infectious Diseases/HIV Infection and AIDS Interferon Interferon Type I - biosynthesis Isoantigens - immunology Lectins, C-Type Leukocytes (mononuclear) Lymphocyte Activation Lymphocytes Lymphocytes T Peripheral blood mononuclear cells Phenotype T cell receptors T cells T-cell receptor T-Lymphocytes - immunology T-Lymphocytes - virology Tryptophan Tryptophan - metabolism Viral infections Viruses
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