Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis

Anthrax meningitis is the main neurological complication of systemic infection with Bacillus anthracis approaching 100% mortality. The presence of bacilli in brain autopsies indicates that vegetative bacteria are able to breach the blood-brain barrier (BBB). The BBB represents not only a physical ba...

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Veröffentlicht in:	PloS one 2008-08, Vol.3 (8), p.e2964-e2964
Hauptverfasser:	van Sorge, Nina M, Ebrahimi, Celia M, McGillivray, Shauna M, Quach, Darin, Sabet, Mojgan, Guiney, Donald G, Doran, Kelly S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anthrax Antigens, Bacterial - pharmacology Autopsies Bacilli Bacillus anthracis Bacteria Bacterial Toxins - pharmacology Biology Blood-brain barrier Blood-Brain Barrier - drug effects Brain Brain - drug effects Brain - physiopathology Central nervous system Cerebrovascular Circulation - drug effects Chemotactic factors Cytokines Development and progression Disseminated infection E coli Edema Endothelial cells Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Enzyme-linked immunosorbent assay Escherichia coli Health aspects Humans Immune response Immune system In vivo methods and tests Infections Infectious Diseases/Bacterial Infections Infectious Diseases/Infectious Diseases of the Nervous System Innate immunity Interleukin 8 Kinases Leukocytes (neutrophilic) Medical treatment Meningitis Meningitis, Bacterial - chemically induced Meningitis, Bacterial - pathology Microbiology/Cellular Microbiology and Pathogenesis Microbiology/Immunity to Infections Microbiology/Innate Immunity Microbiology/Medical Microbiology Microcirculation - drug effects Microvasculature Models, Neurological Motility Mutants Neutrophils Neutrophils - drug effects Neutrophils - physiology Pathogenesis Pediatrics Phosphorylation Plasmids Polymerase chain reaction Proteins Recruitment Signal Transduction - physiology Studies Toxins Transcription Transmission electron microscopy
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