A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calor...

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Veröffentlicht in:PloS one 2008-06, Vol.3 (6), p.e2264-e2264
Hauptverfasser: Barger, Jamie L, Kayo, Tsuyoshi, Vann, James M, Arias, Edward B, Wang, Jelai, Hacker, Timothy A, Wang, Ying, Raederstorff, Daniel, Morrow, Jason D, Leeuwenburgh, Christiaan, Allison, David B, Saupe, Kurt W, Cartee, Gregory D, Weindruch, Richard, Prolla, Tomas A
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container_title PloS one
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creator Barger, Jamie L
Kayo, Tsuyoshi
Vann, James M
Arias, Edward B
Wang, Jelai
Hacker, Timothy A
Wang, Ying
Raederstorff, Daniel
Morrow, Jason D
Leeuwenburgh, Christiaan
Allison, David B
Saupe, Kurt W
Cartee, Gregory D
Weindruch, Richard
Prolla, Tomas A
description Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.
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subjects Age
Aging
Aging - genetics
Animals
Brain
Caenorhabditis elegans
Caloric Restriction
Chromatin
Dehydrogenases
Diabetes
Diet
Dietary restrictions
Drosophila
Endocrine Glands - metabolism
Gene expression
Gene Expression Profiling
Genes
Genetic aspects
Genetics and Genomics/Bioinformatics
Genetics and Genomics/Gene Expression
Genomes
Glucose - metabolism
Health aspects
Heart
Heart diseases
High fat diet
Insects
Insulin
Invertebrates
Kinases
Kinesiology
Life span
Male
Mammals
Medicine
Metabolism
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Middle age
Mortality
Nitric oxide
Nutrition
Nutrition research
Oxidative Stress - drug effects
Phosphorylation
Physiology
Physiology/Physiogenomics
Resveratrol
Rodents
Skeletal muscle
Stilbenes - administration & dosage
Stilbenes - pharmacology
Transcription
Transcription (Genetics)
Transgenic animals
Tumorigenesis
title A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
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