A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calor...
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creator | Barger, Jamie L Kayo, Tsuyoshi Vann, James M Arias, Edward B Wang, Jelai Hacker, Timothy A Wang, Ying Raederstorff, Daniel Morrow, Jason D Leeuwenburgh, Christiaan Allison, David B Saupe, Kurt W Cartee, Gregory D Weindruch, Richard Prolla, Tomas A |
description | Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR. |
doi_str_mv | 10.1371/journal.pone.0002264 |
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We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0002264</identifier><identifier>PMID: 18523577</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aging ; Aging - genetics ; Animals ; Brain ; Caenorhabditis elegans ; Caloric Restriction ; Chromatin ; Dehydrogenases ; Diabetes ; Diet ; Dietary restrictions ; Drosophila ; Endocrine Glands - metabolism ; Gene expression ; Gene Expression Profiling ; Genes ; Genetic aspects ; Genetics and Genomics/Bioinformatics ; Genetics and Genomics/Gene Expression ; Genomes ; Glucose - metabolism ; Health aspects ; Heart ; Heart diseases ; High fat diet ; Insects ; Insulin ; Invertebrates ; Kinases ; Kinesiology ; Life span ; Male ; Mammals ; Medicine ; Metabolism ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Middle age ; Mortality ; Nitric oxide ; Nutrition ; Nutrition research ; Oxidative Stress - drug effects ; Phosphorylation ; Physiology ; Physiology/Physiogenomics ; Resveratrol ; Rodents ; Skeletal muscle ; Stilbenes - administration & dosage ; Stilbenes - pharmacology ; Transcription ; Transcription (Genetics) ; Transgenic animals ; Tumorigenesis</subject><ispartof>PloS one, 2008-06, Vol.3 (6), p.e2264-e2264</ispartof><rights>COPYRIGHT 2008 Public Library of Science</rights><rights>2008 Barger et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Barger et al. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c759t-e29d3bedf621a679239e0a15dd595e77e03ad822021414ee9f66336e6b2b48123</citedby><cites>FETCH-LOGICAL-c759t-e29d3bedf621a679239e0a15dd595e77e03ad822021414ee9f66336e6b2b48123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386967/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386967/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18523577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tomé, Daniel</contributor><creatorcontrib>Barger, Jamie L</creatorcontrib><creatorcontrib>Kayo, Tsuyoshi</creatorcontrib><creatorcontrib>Vann, James M</creatorcontrib><creatorcontrib>Arias, Edward B</creatorcontrib><creatorcontrib>Wang, Jelai</creatorcontrib><creatorcontrib>Hacker, Timothy A</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Raederstorff, Daniel</creatorcontrib><creatorcontrib>Morrow, Jason D</creatorcontrib><creatorcontrib>Leeuwenburgh, Christiaan</creatorcontrib><creatorcontrib>Allison, David B</creatorcontrib><creatorcontrib>Saupe, Kurt W</creatorcontrib><creatorcontrib>Cartee, Gregory D</creatorcontrib><creatorcontrib>Weindruch, Richard</creatorcontrib><creatorcontrib>Prolla, Tomas A</creatorcontrib><title>A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.</description><subject>Age</subject><subject>Aging</subject><subject>Aging - genetics</subject><subject>Animals</subject><subject>Brain</subject><subject>Caenorhabditis elegans</subject><subject>Caloric Restriction</subject><subject>Chromatin</subject><subject>Dehydrogenases</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Dietary restrictions</subject><subject>Drosophila</subject><subject>Endocrine Glands - metabolism</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetics and Genomics/Bioinformatics</subject><subject>Genetics and Genomics/Gene Expression</subject><subject>Genomes</subject><subject>Glucose - metabolism</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>High fat diet</subject><subject>Insects</subject><subject>Insulin</subject><subject>Invertebrates</subject><subject>Kinases</subject><subject>Kinesiology</subject><subject>Life span</subject><subject>Male</subject><subject>Mammals</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred C57BL</subject><subject>Middle age</subject><subject>Mortality</subject><subject>Nitric oxide</subject><subject>Nutrition</subject><subject>Nutrition research</subject><subject>Oxidative Stress - drug effects</subject><subject>Phosphorylation</subject><subject>Physiology</subject><subject>Physiology/Physiogenomics</subject><subject>Resveratrol</subject><subject>Rodents</subject><subject>Skeletal muscle</subject><subject>Stilbenes - administration & dosage</subject><subject>Stilbenes - pharmacology</subject><subject>Transcription</subject><subject>Transcription (Genetics)</subject><subject>Transgenic animals</subject><subject>Tumorigenesis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLwoIXMyYnbdreCMPix8DCgl-3IW1OO1kzzZi0q_vvPXWqzoig9CJN-rxvc76S5DFnSy4K_uLaj6HXbrnzPS4ZYwAyu5Oc8krAQgITdw_eT5IHMV4zlotSyvvJCS9zEHlRnCafV6nzX1PjI6a-TY3FQYfbNGC8waCH4F2602Gw2rnbdGu3tolpo50PtpmggdbB-j7VvaE9aU1MdWf7bpLpLQ4YYmp7kjb4MLnXahfx0byeJR9fv_pw8XZxefVmfbG6XDRFXg0LhMqIGk0rgWtZVCAqZJrnxuRVjkWBTGhTAjDgGc8Qq1ZKISTKGuqs5CDOkqd7353zUc15iooLDlBWTAgi1nvCeH2tdsFuKWjltVU_Dnzo1BR041Ah5C0AcJ7VIgNW66rKKYm8FKIsGpGR18v5b2O9RdNgPwTtjkyPv_R2ozp_o4CKUcmCDM5ng-C_jJRTtbWxQed0j36MquCSSMj_CQJnGZlOV3r2B_j3JCz3VKcpTtu3nq7X0GOQqkVd1Vo6X2UFNVZZlpwEz48ExAz4bej0GKNav3_3_-zVp2P2_IDdoHbDJno3To0Vj8FsDzbBxxiw_ZVlztQ0FD_jVNNQqHkoSPbksEK_RfMUiO86XQdO</recordid><startdate>20080604</startdate><enddate>20080604</enddate><creator>Barger, Jamie L</creator><creator>Kayo, Tsuyoshi</creator><creator>Vann, James M</creator><creator>Arias, Edward B</creator><creator>Wang, Jelai</creator><creator>Hacker, Timothy A</creator><creator>Wang, Ying</creator><creator>Raederstorff, Daniel</creator><creator>Morrow, Jason D</creator><creator>Leeuwenburgh, Christiaan</creator><creator>Allison, David B</creator><creator>Saupe, Kurt W</creator><creator>Cartee, Gregory D</creator><creator>Weindruch, Richard</creator><creator>Prolla, Tomas A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20080604</creationdate><title>A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice</title><author>Barger, Jamie L ; Kayo, Tsuyoshi ; Vann, James M ; Arias, Edward B ; Wang, Jelai ; Hacker, Timothy A ; Wang, Ying ; Raederstorff, Daniel ; Morrow, Jason D ; Leeuwenburgh, Christiaan ; Allison, David B ; Saupe, Kurt W ; Cartee, Gregory D ; Weindruch, Richard ; Prolla, Tomas A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c759t-e29d3bedf621a679239e0a15dd595e77e03ad822021414ee9f66336e6b2b48123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Age</topic><topic>Aging</topic><topic>Aging - 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We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>18523577</pmid><doi>10.1371/journal.pone.0002264</doi><tpages>e2264</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
subjects | Age Aging Aging - genetics Animals Brain Caenorhabditis elegans Caloric Restriction Chromatin Dehydrogenases Diabetes Diet Dietary restrictions Drosophila Endocrine Glands - metabolism Gene expression Gene Expression Profiling Genes Genetic aspects Genetics and Genomics/Bioinformatics Genetics and Genomics/Gene Expression Genomes Glucose - metabolism Health aspects Heart Heart diseases High fat diet Insects Insulin Invertebrates Kinases Kinesiology Life span Male Mammals Medicine Metabolism Mice Mice, Inbred C3H Mice, Inbred C57BL Middle age Mortality Nitric oxide Nutrition Nutrition research Oxidative Stress - drug effects Phosphorylation Physiology Physiology/Physiogenomics Resveratrol Rodents Skeletal muscle Stilbenes - administration & dosage Stilbenes - pharmacology Transcription Transcription (Genetics) Transgenic animals Tumorigenesis |
title | A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice |
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