Identification of nucleolin as new ErbB receptors- interacting protein

The ErbB receptor tyrosine kinases are major contributors to malignant transformation. These receptors are frequently overexpressed in a variety of human carcinomas. The role of the ErbB receptors and their ligands in carcinomas and the mechanism by which their overexpression leads to cancer develop...

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Veröffentlicht in:	PloS one 2008-06, Vol.3 (6), p.e2310-e2310
Hauptverfasser:	Di Segni, Ayelet, Farin, Keren, Pinkas-Kramarski, Ronit
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Analysis Animals Base Sequence Cancer Carcinoma Cell activation Cell Biology/Cell Signaling Cell Division Cell Line Dimerization DNA Primers Epidermal growth factor ErbB protein ErbB-1 protein ErbB-2 protein Fusion protein Gene expression Humans Kinases Ligands Neurobiology Neurosciences Nucleoli Nucleolin Phosphoproteins - metabolism Phosphorylation Phosphotransferases Prostate cancer Protein Binding Proteins Rats Receptor Protein-Tyrosine Kinases - chemistry Receptor Protein-Tyrosine Kinases - metabolism Receptors Recruitment RNA polymerase RNA-Binding Proteins - metabolism Rodents Signal Transduction Spectroscopic analysis Transcription factors Transformation Tyrosine
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