Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats
Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the effects of PRS has been hypothesized for more than 30 years, few studies in this long period have directly addressed the issu...
Gespeichert in:
| Veröffentlicht in: | PloS one 2008-05, Vol.3 (5), p.e2170-e2170 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e2170 |
|---|---|
| container_issue | 5 |
| container_start_page | e2170 |
| container_title | PloS one |
| container_volume | 3 |
| creator | Zuena, Anna Rita Mairesse, Jerome Casolini, Paola Cinque, Carlo Alemà, Giovanni Sebastiano Morley-Fletcher, Sara Chiodi, Valentina Spagnoli, Luigi Giusto Gradini, Roberto Catalani, Assia Nicoletti, Ferdinando Maccari, Stefania |
| description | Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the effects of PRS has been hypothesized for more than 30 years, few studies in this long period have directly addressed the issue. Our group has uncovered a pronounced gender difference in the effects of PRS (stress delivered to the mothers 3 times per day during the last 10 days of pregnancy) on anxiety, spatial learning, and a series of neurobiological parameters classically associated with hippocampus-dependent behaviors. Adult male rats subjected to PRS ("PRS rats") showed increased anxiety-like behavior in the elevated plus maze (EPM), a reduction in the survival of newborn cells in the dentate gyrus, a reduction in the activity of mGlu1/5 metabotropic glutamate receptors in the ventral hippocampus, and an increase in the levels of brain-derived neurotrophic factor (BDNF) and pro-BDNF in the hippocampus. In contrast, female PRS rats displayed reduced anxiety in the EPM, improved learning in the Morris water maze, an increase in the activity of mGlu1/5 receptors in the ventral and dorsal hippocampus, and no changes in hippocampal neurogenesis or BDNF levels. The direction of the changes in neurogenesis, BDNF levels and mGlu receptor function in PRS animals was not consistent with the behavioral changes, suggesting that PRS perturbs the interdependency of these particular parameters and their relation to hippocampus-dependent behavior. Our data suggest that the epigenetic changes in hippocampal neuroplasticity induced by early environmental challenges are critically sex-dependent and that the behavioral outcome may diverge in males and females. |
| doi_str_mv | 10.1371/journal.pone.0002170 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1312287721</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A472650626</galeid><doaj_id>oai_doaj_org_article_564586bc1bec48f3a1b98d7a8fa863c5</doaj_id><sourcerecordid>A472650626</sourcerecordid><originalsourceid>FETCH-LOGICAL-c728t-3722b7a0b7686fd4642676e1bb7ae04bf3423c4f065e6a0e6c6224cd38691cfe3</originalsourceid><addsrcrecordid>eNqNkl2LEzEUhgdR3A_9B6IDwoIXrfmaZHojLMuqhYUVv25DJnPSpqRJN8ms-u9N21Fb8ULmIuHM877hnPNW1TOMppgK_HoVhuiVm26ChylCiGCBHlSneEbJhBNEHx7cT6qzlFYINbTl_HF1glsmWozJaeU_RPAqK1dHSDkq63NdTkipXoCHqDKkOn8LdW9Ttl7nuoOlurchFonyfe1hiEEvYW11qWxiMNYVifX1WjnYIQZ21-KVnlSPjHIJno7nefXl7fXnq_eTm9t386vLm4kWpM0TKgjphEKd4C03PeOMcMEBd6UIiHWGMkI1M4g3wBUCrjkhTPelvRnWBuh59WLvu3EhyXFUSWKKCWmFILgQ8z3RB7WSm2jXKv6QQVm5K4S4kCpmqx3IhrOm5Z3GHWjWGqpwN2t7oVqjWk51U7zejK8N3Rp6Db5M0h2ZHv_xdikX4V4SyjnirBhcjAYx3A1lEXJtkwbnlIcwJCmQoKRpUAFf_gX-u7fpnlqUuUvrTSiv6vL12zWVvGx3JC-ZILxBnPAieHUkKEyG73mhhpTk_NPH_2dvvx6zFwfsEpTLyxTckG3w6Rhke1DHkFIE83t4GMlt3H_1Kbdxl2Pci-z54eD_iMZ805-9i_zY</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1312287721</pqid></control><display><type>article</type><title>Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats</title><source>PLoS</source><source>MEDLINE</source><source>Full-Text Journals in Chemistry (Open access)</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>Zuena, Anna Rita ; Mairesse, Jerome ; Casolini, Paola ; Cinque, Carlo ; Alemà, Giovanni Sebastiano ; Morley-Fletcher, Sara ; Chiodi, Valentina ; Spagnoli, Luigi Giusto ; Gradini, Roberto ; Catalani, Assia ; Nicoletti, Ferdinando ; Maccari, Stefania</creator><contributor>Cookson, Mark R.</contributor><creatorcontrib>Zuena, Anna Rita ; Mairesse, Jerome ; Casolini, Paola ; Cinque, Carlo ; Alemà, Giovanni Sebastiano ; Morley-Fletcher, Sara ; Chiodi, Valentina ; Spagnoli, Luigi Giusto ; Gradini, Roberto ; Catalani, Assia ; Nicoletti, Ferdinando ; Maccari, Stefania ; Cookson, Mark R.</creatorcontrib><description>Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the effects of PRS has been hypothesized for more than 30 years, few studies in this long period have directly addressed the issue. Our group has uncovered a pronounced gender difference in the effects of PRS (stress delivered to the mothers 3 times per day during the last 10 days of pregnancy) on anxiety, spatial learning, and a series of neurobiological parameters classically associated with hippocampus-dependent behaviors. Adult male rats subjected to PRS ("PRS rats") showed increased anxiety-like behavior in the elevated plus maze (EPM), a reduction in the survival of newborn cells in the dentate gyrus, a reduction in the activity of mGlu1/5 metabotropic glutamate receptors in the ventral hippocampus, and an increase in the levels of brain-derived neurotrophic factor (BDNF) and pro-BDNF in the hippocampus. In contrast, female PRS rats displayed reduced anxiety in the EPM, improved learning in the Morris water maze, an increase in the activity of mGlu1/5 receptors in the ventral and dorsal hippocampus, and no changes in hippocampal neurogenesis or BDNF levels. The direction of the changes in neurogenesis, BDNF levels and mGlu receptor function in PRS animals was not consistent with the behavioral changes, suggesting that PRS perturbs the interdependency of these particular parameters and their relation to hippocampus-dependent behavior. Our data suggest that the epigenetic changes in hippocampal neuroplasticity induced by early environmental challenges are critically sex-dependent and that the behavioral outcome may diverge in males and females.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0002170</identifier><identifier>PMID: 18478112</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amino acids ; Animal behavior ; Animals ; Animals, Newborn ; Anxieties ; Anxiety ; Behavior ; Behavioral plasticity ; Brain ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - metabolism ; Cell Biology/Cellular Death and Stress Responses ; Cell Biology/Neuronal and Glial Cell Biology ; Cell Biology/Neuronal Signaling Mechanisms ; Cell Differentiation ; Cell survival ; Chemical Biology/Protein Chemistry and Proteomics ; Dentate gyrus ; Developmental Biology/Neurodevelopment ; Diabetes and Endocrinology/Neuroendocrinology and Pituitary ; Diabetes and Endocrinology/Type 2 Diabetes ; Dimorphism ; Female ; Females ; Gender ; Genetics and Genomics/Epigenetics ; Glutamate ; Glutamic acid receptors (metabotropic) ; Hippocampal plasticity ; Hippocampus ; Hippocampus - cytology ; Hippocampus - metabolism ; Histology ; Hydrolysis ; Immobilization ; Learning ; Male ; Males ; Maze learning ; Memory ; Mental Health/Anxiety Disorders ; Mental Health/Psychopharmacology ; Metabolism ; Nervous system ; Neurobiology ; Neurogenesis ; Neuroplasticity ; Neuroscience/Neural Homeostasis ; Neuroscience/Neurobiology of Disease and Regeneration ; Neuroscience/Neuronal and Glial Cell Biology ; Neuroscience/Neuronal Signaling Mechanisms ; Pharmacology ; Phenols ; Phosphatidylinositol Phosphates - metabolism ; Physiology ; Physiology/Endocrinology ; Pregnancy ; Prenatal experience ; Prenatal Exposure Delayed Effects ; Rats ; Rats, Sprague-Dawley ; Receptor, Metabotropic Glutamate 5 ; Receptors ; Receptors, Metabotropic Glutamate - metabolism ; Reduction ; Rodents ; Sex Factors ; Sexual dimorphism ; Spatial discrimination learning ; Spatial memory ; Stress ; Stresses</subject><ispartof>PloS one, 2008-05, Vol.3 (5), p.e2170-e2170</ispartof><rights>COPYRIGHT 2008 Public Library of Science</rights><rights>2008 Zuena et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Zuena et al. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c728t-3722b7a0b7686fd4642676e1bb7ae04bf3423c4f065e6a0e6c6224cd38691cfe3</citedby><cites>FETCH-LOGICAL-c728t-3722b7a0b7686fd4642676e1bb7ae04bf3423c4f065e6a0e6c6224cd38691cfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366064/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366064/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2919,23857,27915,27916,53782,53784,79361,79362</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18478112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cookson, Mark R.</contributor><creatorcontrib>Zuena, Anna Rita</creatorcontrib><creatorcontrib>Mairesse, Jerome</creatorcontrib><creatorcontrib>Casolini, Paola</creatorcontrib><creatorcontrib>Cinque, Carlo</creatorcontrib><creatorcontrib>Alemà, Giovanni Sebastiano</creatorcontrib><creatorcontrib>Morley-Fletcher, Sara</creatorcontrib><creatorcontrib>Chiodi, Valentina</creatorcontrib><creatorcontrib>Spagnoli, Luigi Giusto</creatorcontrib><creatorcontrib>Gradini, Roberto</creatorcontrib><creatorcontrib>Catalani, Assia</creatorcontrib><creatorcontrib>Nicoletti, Ferdinando</creatorcontrib><creatorcontrib>Maccari, Stefania</creatorcontrib><title>Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the effects of PRS has been hypothesized for more than 30 years, few studies in this long period have directly addressed the issue. Our group has uncovered a pronounced gender difference in the effects of PRS (stress delivered to the mothers 3 times per day during the last 10 days of pregnancy) on anxiety, spatial learning, and a series of neurobiological parameters classically associated with hippocampus-dependent behaviors. Adult male rats subjected to PRS ("PRS rats") showed increased anxiety-like behavior in the elevated plus maze (EPM), a reduction in the survival of newborn cells in the dentate gyrus, a reduction in the activity of mGlu1/5 metabotropic glutamate receptors in the ventral hippocampus, and an increase in the levels of brain-derived neurotrophic factor (BDNF) and pro-BDNF in the hippocampus. In contrast, female PRS rats displayed reduced anxiety in the EPM, improved learning in the Morris water maze, an increase in the activity of mGlu1/5 receptors in the ventral and dorsal hippocampus, and no changes in hippocampal neurogenesis or BDNF levels. The direction of the changes in neurogenesis, BDNF levels and mGlu receptor function in PRS animals was not consistent with the behavioral changes, suggesting that PRS perturbs the interdependency of these particular parameters and their relation to hippocampus-dependent behavior. Our data suggest that the epigenetic changes in hippocampal neuroplasticity induced by early environmental challenges are critically sex-dependent and that the behavioral outcome may diverge in males and females.</description><subject>Amino acids</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Anxieties</subject><subject>Anxiety</subject><subject>Behavior</subject><subject>Behavioral plasticity</subject><subject>Brain</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Cell Biology/Cellular Death and Stress Responses</subject><subject>Cell Biology/Neuronal and Glial Cell Biology</subject><subject>Cell Biology/Neuronal Signaling Mechanisms</subject><subject>Cell Differentiation</subject><subject>Cell survival</subject><subject>Chemical Biology/Protein Chemistry and Proteomics</subject><subject>Dentate gyrus</subject><subject>Developmental Biology/Neurodevelopment</subject><subject>Diabetes and Endocrinology/Neuroendocrinology and Pituitary</subject><subject>Diabetes and Endocrinology/Type 2 Diabetes</subject><subject>Dimorphism</subject><subject>Female</subject><subject>Females</subject><subject>Gender</subject><subject>Genetics and Genomics/Epigenetics</subject><subject>Glutamate</subject><subject>Glutamic acid receptors (metabotropic)</subject><subject>Hippocampal plasticity</subject><subject>Hippocampus</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - metabolism</subject><subject>Histology</subject><subject>Hydrolysis</subject><subject>Immobilization</subject><subject>Learning</subject><subject>Male</subject><subject>Males</subject><subject>Maze learning</subject><subject>Memory</subject><subject>Mental Health/Anxiety Disorders</subject><subject>Mental Health/Psychopharmacology</subject><subject>Metabolism</subject><subject>Nervous system</subject><subject>Neurobiology</subject><subject>Neurogenesis</subject><subject>Neuroplasticity</subject><subject>Neuroscience/Neural Homeostasis</subject><subject>Neuroscience/Neurobiology of Disease and Regeneration</subject><subject>Neuroscience/Neuronal and Glial Cell Biology</subject><subject>Neuroscience/Neuronal Signaling Mechanisms</subject><subject>Pharmacology</subject><subject>Phenols</subject><subject>Phosphatidylinositol Phosphates - metabolism</subject><subject>Physiology</subject><subject>Physiology/Endocrinology</subject><subject>Pregnancy</subject><subject>Prenatal experience</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor, Metabotropic Glutamate 5</subject><subject>Receptors</subject><subject>Receptors, Metabotropic Glutamate - metabolism</subject><subject>Reduction</subject><subject>Rodents</subject><subject>Sex Factors</subject><subject>Sexual dimorphism</subject><subject>Spatial discrimination learning</subject><subject>Spatial memory</subject><subject>Stress</subject><subject>Stresses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2LEzEUhgdR3A_9B6IDwoIXrfmaZHojLMuqhYUVv25DJnPSpqRJN8ms-u9N21Fb8ULmIuHM877hnPNW1TOMppgK_HoVhuiVm26ChylCiGCBHlSneEbJhBNEHx7cT6qzlFYINbTl_HF1glsmWozJaeU_RPAqK1dHSDkq63NdTkipXoCHqDKkOn8LdW9Ttl7nuoOlurchFonyfe1hiEEvYW11qWxiMNYVifX1WjnYIQZ21-KVnlSPjHIJno7nefXl7fXnq_eTm9t386vLm4kWpM0TKgjphEKd4C03PeOMcMEBd6UIiHWGMkI1M4g3wBUCrjkhTPelvRnWBuh59WLvu3EhyXFUSWKKCWmFILgQ8z3RB7WSm2jXKv6QQVm5K4S4kCpmqx3IhrOm5Z3GHWjWGqpwN2t7oVqjWk51U7zejK8N3Rp6Db5M0h2ZHv_xdikX4V4SyjnirBhcjAYx3A1lEXJtkwbnlIcwJCmQoKRpUAFf_gX-u7fpnlqUuUvrTSiv6vL12zWVvGx3JC-ZILxBnPAieHUkKEyG73mhhpTk_NPH_2dvvx6zFwfsEpTLyxTckG3w6Rhke1DHkFIE83t4GMlt3H_1Kbdxl2Pci-z54eD_iMZ805-9i_zY</recordid><startdate>20080514</startdate><enddate>20080514</enddate><creator>Zuena, Anna Rita</creator><creator>Mairesse, Jerome</creator><creator>Casolini, Paola</creator><creator>Cinque, Carlo</creator><creator>Alemà, Giovanni Sebastiano</creator><creator>Morley-Fletcher, Sara</creator><creator>Chiodi, Valentina</creator><creator>Spagnoli, Luigi Giusto</creator><creator>Gradini, Roberto</creator><creator>Catalani, Assia</creator><creator>Nicoletti, Ferdinando</creator><creator>Maccari, Stefania</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20080514</creationdate><title>Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats</title><author>Zuena, Anna Rita ; Mairesse, Jerome ; Casolini, Paola ; Cinque, Carlo ; Alemà, Giovanni Sebastiano ; Morley-Fletcher, Sara ; Chiodi, Valentina ; Spagnoli, Luigi Giusto ; Gradini, Roberto ; Catalani, Assia ; Nicoletti, Ferdinando ; Maccari, Stefania</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c728t-3722b7a0b7686fd4642676e1bb7ae04bf3423c4f065e6a0e6c6224cd38691cfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Amino acids</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Anxieties</topic><topic>Anxiety</topic><topic>Behavior</topic><topic>Behavioral plasticity</topic><topic>Brain</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Cell Biology/Cellular Death and Stress Responses</topic><topic>Cell Biology/Neuronal and Glial Cell Biology</topic><topic>Cell Biology/Neuronal Signaling Mechanisms</topic><topic>Cell Differentiation</topic><topic>Cell survival</topic><topic>Chemical Biology/Protein Chemistry and Proteomics</topic><topic>Dentate gyrus</topic><topic>Developmental Biology/Neurodevelopment</topic><topic>Diabetes and Endocrinology/Neuroendocrinology and Pituitary</topic><topic>Diabetes and Endocrinology/Type 2 Diabetes</topic><topic>Dimorphism</topic><topic>Female</topic><topic>Females</topic><topic>Gender</topic><topic>Genetics and Genomics/Epigenetics</topic><topic>Glutamate</topic><topic>Glutamic acid receptors (metabotropic)</topic><topic>Hippocampal plasticity</topic><topic>Hippocampus</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - metabolism</topic><topic>Histology</topic><topic>Hydrolysis</topic><topic>Immobilization</topic><topic>Learning</topic><topic>Male</topic><topic>Males</topic><topic>Maze learning</topic><topic>Memory</topic><topic>Mental Health/Anxiety Disorders</topic><topic>Mental Health/Psychopharmacology</topic><topic>Metabolism</topic><topic>Nervous system</topic><topic>Neurobiology</topic><topic>Neurogenesis</topic><topic>Neuroplasticity</topic><topic>Neuroscience/Neural Homeostasis</topic><topic>Neuroscience/Neurobiology of Disease and Regeneration</topic><topic>Neuroscience/Neuronal and Glial Cell Biology</topic><topic>Neuroscience/Neuronal Signaling Mechanisms</topic><topic>Pharmacology</topic><topic>Phenols</topic><topic>Phosphatidylinositol Phosphates - metabolism</topic><topic>Physiology</topic><topic>Physiology/Endocrinology</topic><topic>Pregnancy</topic><topic>Prenatal experience</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor, Metabotropic Glutamate 5</topic><topic>Receptors</topic><topic>Receptors, Metabotropic Glutamate - metabolism</topic><topic>Reduction</topic><topic>Rodents</topic><topic>Sex Factors</topic><topic>Sexual dimorphism</topic><topic>Spatial discrimination learning</topic><topic>Spatial memory</topic><topic>Stress</topic><topic>Stresses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zuena, Anna Rita</creatorcontrib><creatorcontrib>Mairesse, Jerome</creatorcontrib><creatorcontrib>Casolini, Paola</creatorcontrib><creatorcontrib>Cinque, Carlo</creatorcontrib><creatorcontrib>Alemà, Giovanni Sebastiano</creatorcontrib><creatorcontrib>Morley-Fletcher, Sara</creatorcontrib><creatorcontrib>Chiodi, Valentina</creatorcontrib><creatorcontrib>Spagnoli, Luigi Giusto</creatorcontrib><creatorcontrib>Gradini, Roberto</creatorcontrib><creatorcontrib>Catalani, Assia</creatorcontrib><creatorcontrib>Nicoletti, Ferdinando</creatorcontrib><creatorcontrib>Maccari, Stefania</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zuena, Anna Rita</au><au>Mairesse, Jerome</au><au>Casolini, Paola</au><au>Cinque, Carlo</au><au>Alemà, Giovanni Sebastiano</au><au>Morley-Fletcher, Sara</au><au>Chiodi, Valentina</au><au>Spagnoli, Luigi Giusto</au><au>Gradini, Roberto</au><au>Catalani, Assia</au><au>Nicoletti, Ferdinando</au><au>Maccari, Stefania</au><au>Cookson, Mark R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2008-05-14</date><risdate>2008</risdate><volume>3</volume><issue>5</issue><spage>e2170</spage><epage>e2170</epage><pages>e2170-e2170</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the effects of PRS has been hypothesized for more than 30 years, few studies in this long period have directly addressed the issue. Our group has uncovered a pronounced gender difference in the effects of PRS (stress delivered to the mothers 3 times per day during the last 10 days of pregnancy) on anxiety, spatial learning, and a series of neurobiological parameters classically associated with hippocampus-dependent behaviors. Adult male rats subjected to PRS ("PRS rats") showed increased anxiety-like behavior in the elevated plus maze (EPM), a reduction in the survival of newborn cells in the dentate gyrus, a reduction in the activity of mGlu1/5 metabotropic glutamate receptors in the ventral hippocampus, and an increase in the levels of brain-derived neurotrophic factor (BDNF) and pro-BDNF in the hippocampus. In contrast, female PRS rats displayed reduced anxiety in the EPM, improved learning in the Morris water maze, an increase in the activity of mGlu1/5 receptors in the ventral and dorsal hippocampus, and no changes in hippocampal neurogenesis or BDNF levels. The direction of the changes in neurogenesis, BDNF levels and mGlu receptor function in PRS animals was not consistent with the behavioral changes, suggesting that PRS perturbs the interdependency of these particular parameters and their relation to hippocampus-dependent behavior. Our data suggest that the epigenetic changes in hippocampal neuroplasticity induced by early environmental challenges are critically sex-dependent and that the behavioral outcome may diverge in males and females.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>18478112</pmid><doi>10.1371/journal.pone.0002170</doi><tpages>e2170</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2008-05, Vol.3 (5), p.e2170-e2170 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1312287721 |
| source | PLoS; MEDLINE; Full-Text Journals in Chemistry (Open access); DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library |
| subjects | Amino acids Animal behavior Animals Animals, Newborn Anxieties Anxiety Behavior Behavioral plasticity Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cell Biology/Cellular Death and Stress Responses Cell Biology/Neuronal and Glial Cell Biology Cell Biology/Neuronal Signaling Mechanisms Cell Differentiation Cell survival Chemical Biology/Protein Chemistry and Proteomics Dentate gyrus Developmental Biology/Neurodevelopment Diabetes and Endocrinology/Neuroendocrinology and Pituitary Diabetes and Endocrinology/Type 2 Diabetes Dimorphism Female Females Gender Genetics and Genomics/Epigenetics Glutamate Glutamic acid receptors (metabotropic) Hippocampal plasticity Hippocampus Hippocampus - cytology Hippocampus - metabolism Histology Hydrolysis Immobilization Learning Male Males Maze learning Memory Mental Health/Anxiety Disorders Mental Health/Psychopharmacology Metabolism Nervous system Neurobiology Neurogenesis Neuroplasticity Neuroscience/Neural Homeostasis Neuroscience/Neurobiology of Disease and Regeneration Neuroscience/Neuronal and Glial Cell Biology Neuroscience/Neuronal Signaling Mechanisms Pharmacology Phenols Phosphatidylinositol Phosphates - metabolism Physiology Physiology/Endocrinology Pregnancy Prenatal experience Prenatal Exposure Delayed Effects Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors Receptors, Metabotropic Glutamate - metabolism Reduction Rodents Sex Factors Sexual dimorphism Spatial discrimination learning Spatial memory Stress Stresses |
| title | Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T19%3A37%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prenatal%20restraint%20stress%20generates%20two%20distinct%20behavioral%20and%20neurochemical%20profiles%20in%20male%20and%20female%20rats&rft.jtitle=PloS%20one&rft.au=Zuena,%20Anna%20Rita&rft.date=2008-05-14&rft.volume=3&rft.issue=5&rft.spage=e2170&rft.epage=e2170&rft.pages=e2170-e2170&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0002170&rft_dat=%3Cgale_plos_%3EA472650626%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1312287721&rft_id=info:pmid/18478112&rft_galeid=A472650626&rft_doaj_id=oai_doaj_org_article_564586bc1bec48f3a1b98d7a8fa863c5&rfr_iscdi=true |