Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy

The development of a safe and effective AD vaccine requires a delicate balance between providing an adequate anti-Abeta antibody response sufficient to provide therapeutic benefit, while eliminating an adverse T cell-mediated proinflammatory autoimmune response. To achieve this goal we have designed...

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Veröffentlicht in:	PloS one 2008-05, Vol.3 (5), p.e2124-e2124
Hauptverfasser:	Movsesyan, Nina, Ghochikyan, Anahit, Mkrtichyan, Mikayel, Petrushina, Irina, Davtyan, Hayk, Olkhanud, Purevdorj B, Head, Elizabeth, Biragyn, Arya, Cribbs, David H, Agadjanyan, Michael G
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Aging Alzheimer Disease - genetics Alzheimer Disease - immunology Alzheimer Disease - pathology Alzheimer's disease Analysis Animal behavior Animals Antibody response Antigenic determinants Antigens Autoimmunity B cells CCL22 protein Chemokines Clinical trials Clinical Trials as Topic Dementia Deoxyribonucleic acid Disease Models, Animal DNA DNA vaccines Epitopes Epitopes - therapeutic use Fusion protein Health aspects Helper cells Humans Humoral immunity Immune response Immune system Immunity Immunization Immunology Immunology/Immune Response Immunotherapy Immunotherapy - methods Inflammation Laboratories Lymphocytes Lymphocytes B Lymphocytes T Macrophages Malaria Vaccines - immunology Medical research Medicine Mice Mice, Transgenic Neurological Disorders/Alzheimer Disease Pathology Peptides Proteins T cell receptors T cells T-Lymphocytes - immunology Vaccination Vaccines Vaccines, DNA - therapeutic use
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